宿主微生物失调在 SIV 感染相关肠病中的作用-猫眼课题宝

宿主微生物失调在 SIV 感染相关肠病中的作用

批准号：

8467517

负责人：

Michael D. George

金额：

$23.1万

依托单位：

UNIVERSITY OF CALIFORNIA AT DAVIS

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-02-01 至 2015-01-31

来源：

https://reporter.nih.gov/project-details/8467517

关键词：

Acquired Immunodeficiency Syndrome Acute Agonist Animals Archives Bacteria Biology CD4 Positive T Lymphocytes Chronic Clinical Trials Communication Communities Cryopreserved Tissue Data Analyses Defensins Development Diarrhea Disease Progression Epithelial Cells Epithelium Flagellin Gene Expression Gut associated lymphoid tissue HIV Health Transition Immune response Immunohistochemistry Immunologic Deficiency Syndromes Individual Infection Inflammation Inflammatory Intestines Kinetics Lead Macaca Macaca mulatta Malnutrition Metabolic Microbe Modeling Molecular Molecular Profiling Mucins Mucous Membrane Muramidase Natural Immunity Pathogenesis Pathway interactions Patients Phylogenetic Analysis Population Proteins Repression Research Reverse Transcriptase Polymerase Chain Reaction Ribosomal RNA Role SIV Sequence Analysis Shapes Small Intestines Staging Structure Surface System Systems Biology T-Cell Depletion Testing Therapeutic Tissue Sample Villus Virus Diseases adaptive immunity antimicrobial arm base fimbria innovation insight intestinal epithelium jejunum laser capture microdissection metabolic abnormality assessment microbial microbiome pathogenic bacteria public health relevance response

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中文摘要

翻译

描述（由申请人提供）：尽管HIV相关肠病被认为会加速疾病进展，并且是全球患者腹泻和营养不良的主要原因，但对发病机制的动力学和分子机制仍知之甚少。我们假设宿主适应性免疫和先天免疫与肠道微生物群（生态失调）之间的平衡失调是免疫缺陷病毒感染引起肠病的根本原因。拟议的研究将利用系统生物学方法来验证这一假设，表征肠道生态失调的微生物特征及其在SIV感染恒河猴模型中肠病中的作用机制。这项研究的结果将为SIV和HIV感染中肠病的分子和细胞基础提供前所未有的见解。

英文摘要

DESCRIPTION (provided by applicant): Although HIV-associated enteropathy is presumed to enhance disease progression and is a major cause of diarrhea and malnutrition in patients world-wide, the kinetics and molecular mechanisms of pathogenesis remain poorly understood. We hypothesize that disruption of homeostatic trialogue between host adaptive and innate immunity and the intestinal microbiota (dysbiosis) is an underlying cause of enteropathy in immunodeficiency virus infection. The proposed research will utilize a systems biology approach to test this hypothesis, characterizing the microbial signature of intestinal dysbiosis and the mechanisms of its role in enteropathy in the SIV infected rhesus macaque model. Findings from the study will provide unprecedented insights into the molecular and cellular basis of enteropathy in SIV and HIV infection.

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