Cellular & Molecular Biology Core

这项申请要求支持继续密歇根大学细胞和分子生物学（CMB）核心的生产性工作，以加强NIDCD面向任务的研究。该提案建立在前两个P30资助期的经验基础上，细胞与分子生物学（CMB）核心将继续通过其四个目标为用户群服务： 目标1：提高和扩大核心参与者个人研究项目的质量和范围 目标2：提高用户群体内研究的效率和生产力 目标3：制定方法和办法，以满足当前用户的需要并预测未来的需要 目标4：提供教育，发展合作，吸引新人进入该领域 新的未来五年，CMB核心是增加前庭组织和组织与化学感官的处理和评估，以反映用户群的需求。Kohrman博士将取代Lomax博士担任联席主任，所提供的分子生物学咨询可以扩展到包括有关开发和使用转基因小鼠的信息。资本市场管理局将继续为调查人员提供新的方法和途径，并开发技术、数据库和共享资源。它将提供有关方法学新进展的信息给个体研究者，在常规和新型分子方法学方面培训个体研究者的工作人员，并为新型和先进方法学提供与密歇根大学中心化设施的桥梁。它将为形态学和分子学评估提供最先进的支持，提供规范性数据库，并在实验设计和结果解释方面提供帮助。它将利用科学协同核心和与合格用户的定期会议，介绍新的方法和做法，分享经验、问题和成功，并发展新的富有成效的合作。CMB的服务和介绍将继续为听力，平衡和化学感官研究带来新的研究人员。CMB核心还将与生理学核心密切合作，协调动物的生理，行为，形态和分子特征，以提高我们对听觉，平衡和化学感官的理解，并确定预防和治疗其疾病的分子干预措施。

This application requests support to continue the productive work of the University of Michigan Cell & Molecular Biology (CMB) Core to enhance NIDCD-mission oriented research. The proposal builds on experience gained from the two previous P30 grant periods The Cell & Molecular Biology (CMB) Core will continue to serve the user base through its four aims: Aim 1: Enhance and extend the quality and scope of the individual research projects of Core participants Aim 2: Improve efficiency and productivity of research within the user group Aim 3: Develop methods and approaches to meet current user needs and to anticipate future needs Aim 4: Provide education, develop collaborations and bring new people into the field New to the next five years, the CMB Core is adding processing and assessment of vestibular tissues and tissues associated with the chemical senses, to reflect the needs of the user base. Dr. Kohrman is replacing Dr. Lomax as the co-Director and the molecular biology consultation offered can expand to include information on developing and using transgenic mice. The CMB will continue to bring new methods and approaches to individual investigators and develop technology, data bases and shared resources. It will provide information on new advances in methodology to individual investigators, train staff of individual investigators in both routine and novel molecular methodologies and provide a bridge to centralized University of Michigan facilities for novel and advanced methodologies. It will provide state-of-the-art support for morphological and molecular assessments, provide normative data bases and provide assistance in experimental design and interpretation of results. It will use the Scientific Synergy Core and periodic meetings with qualified users to present new methods and approaches, share experiences, problems and successes and develop new productive collaborations. The CMB services and presentations will continue to bring new investigators to the study of hearing, balance and chemical senses research. The CMB Core will also work closely with the Physiology Core to coordinate physiological, behavioral, morphological and molecular characterization of animals to enhance our understanding of hearing, balance and chemical senses and to define molecular interventions that will prevent and treat their disorders.