Reproductive Biology and Genomics Training Program

说明(申请人提供)：该计划续期的总体目标是继续提供全面和深入的生殖科学研究培训，集中整合哺乳动物功能基因组学/遗传学和计算生物学工具方面的培训。为实现这一目标，一批经过挑选的研究生和博士后受训人员将有机会选择双重导师并接受其培训：初级培训员具有生殖科学方面的专门知识，联合培训员具有基因组学和(或)计算生物学方面的专门知识。本申请中有十八(18)名教师培训师。我们请求支持两(2)个学士学位博士和三(3)个博士后职位(其中一个是为MD/DVM寻求博士实习生保留的)，每个职位为期两年的培训间隔。本培训计划要求提供总计五(5)年的支持。这项拟议培训计划背后的理念是基于这样一种认识，即生殖科学中的生物医学研究人员将从全基因组调查技术的实际和应用方面的平行培训中受益匪浅。康奈尔大学为生殖科学的培训项目做好了独一无二的准备，该项目涵盖男性和女性生理学、生育的遗传基础、母胎界面的生理学、细胞信号和分子内分泌学，以及生殖癌症的分子和遗传学基础。此外，拟议的计划将极大地受益于将对果蝇和线虫的非哺乳动物繁殖模式感兴趣的教职员工纳入其中，以促进比较进化研究。基因组学和计算领域的培训将侧重于以下(一些例子)：创建和使用转基因和基因敲除模型(用于研究生育能力的动物模型以及侧重生殖肿瘤的疾病病理生理学模型)；利用微阵列和生物信息学分析，包括在操作模式生物数据库和帮助确定基因/表型关系的基因组浏览器/门户网站方面进行全面培训；建立计算机模拟，以便于就结构/功能关系作出知情决定；根据比较基因组学原理分析基因转录网络。参与这一拟议计划的教员致力于促进生殖科学的培训环境及其与基因组结构和活动的联系。培训师和协训者之间的合作努力(S)是这个项目的基石。这种独特的科学和技术接口将增加博士后和博士后学员离开这个环境的机会，他们在生殖科学和多种最先进的技术和基因组学应用方面接受过良好的培训，这将使他们在继续培训(过渡到博士后)或 在学术界、政府或工业中获得科学职位。 公共卫生相关性：该培训方案的目标是继续提供全面和深入的生殖科学研究培训，集中整合功能哺乳动物基因组学/遗传学和计算生物学工具的培训，以解决世界人口、长期可持续性和不孕不育等问题。为此目的，毕业生和博士后受训者将选择双重导师，并接受双重导师的培训；初级培训者具有生殖科学方面的专门知识，而共同培训者具有基因组学和(或)计算生物学方面的专门知识。

DESCRIPTION (provided by applicant): The overall goal of the renewal of this Program is to continue to provide comprehensive and in-depth research training in the reproductive sciences, centrally integrating training in the tools of functional mammalian genomics/genetics and computational biology. To accomplish this goal, a select group of graduate and postdoctoral trainees will have the opportunity to choose and be trained by dual mentors; the primary Trainer having expertise in the reproductive sciences and the Co-Trainer with expertise in genomics and/or computational biology. Eighteen (18) faculty trainers are represented in this application. We are requesting support for two (2) baccalaureate PhD slots and three (3) postdoctoral slots (one of which is reserved for a MD/DVM-Seeking-PhD trainee), each for a two-year training interval. Support is requested for a total of five (5) years for this training program. The philosophy behind this proposed training plan is based upon the appreciation that biomedical researchers in the reproductive sciences would benefit greatly from parallel training in practical and applied use of genome-wide investigative techniques. Cornell University is uniquely poised for a training program in reproductive sciences that spans male and female physiology, the genetic bases of fertility, physiology of the maternal-fetal interface, cell signaling and molecula endocrinology and the molecular and genetic basis for reproductive cancers. In addition, the proposed program will benefit greatly by inclusion of faculty members with interests in non-mammalian models of reproduction in Drosophila and C. elegans to facilitate comparative evolutionary studies. Training in the genomics and computational areas will emphasize the following (some examples): creation and use of transgenic and knockout models (animal models for the study of fertility as well as models of disease pathophysiology emphasizing reproductive neoplasia); use of micro arrays and bioinformatics analyses including comprehensive training in manipulation of databases for model organisms and genomic browsers/portals that serve to aid in determination of genotype/phenotype relationships; creation of computer-based modeling to facilitate informed decisions on structure/function relationships; analysis of gene transcription networks based upon application of principles of comparative genomics. The faculty involved in this proposed Program is committed to facilitating a training environment in the reproductive sciences and its interface with genome structure and activity. The collaborative effort(s) between Trainers and coTrainers is the cornerstone of this program. This unique scientific and technical interface will enhance the opportunity for pre- and postdoctoral trainees to leave this environment well-trained in the reproductive sciences and in multiple state-of-the-art techniques and applications in genomics that will optimize their continued success in continued training (transitioning to postdoctoral) or the acquisition of scientific positions in academia, government or industry. PUBLIC HEALTH RELEVANCE: The goal of this training Program is to continue to provide comprehensive and in-depth research training in the reproductive sciences, centrally integrating training in the tools of functional mammalian genomics/genetics and computational biology in order to address problems of world population, long-term sustainability and infertility. To this end, graduate and postdoctoral trainees will choose and be trained by dual mentors; the primary Trainer having expertise in the reproductive sciences and the Co-Trainer with expertise in genomics and/or computational biology.