Pathophysiology and Rehabilitation of Neural Dysfunction

描述（由申请人提供）：本提案旨在为我们的病理生理学和神经功能障碍康复（PRND）培训计划的第五周期提供资金。该计划由Eric Perreault博士指导，并由CJ Heckman博士和托德Kuiken博士共同指导。学员将由23名高度合作的导师指导，涵盖从细胞神经生理学到工程学，再到临床医学的各个领域，所有这些都侧重于神经功能障碍的康复。我们计划的具体目标是培养康复科学家，他们了解神经残疾人面临的广泛问题，并拥有临床，科学和定量技能，以减轻这一不断增长的人口的负担。该项目设在西北大学，与芝加哥康复研究所密切合作。这两个机构在尖端康复研究方面有着悠久的合作历史，或项目对此做出了贡献。在我们的前4个资助周期中，该计划直接支持了34名博士前研究员，24名博士后研究员和5名暑期实习生。这些学员中有许多人现在已成为康复医学领域的领导者。在这次更新申请中，我们寻求建立在我们过去的成就基础上，并通过创新来增加我们的影响力，这些创新旨在正式确定我们培训计划的临床部分，增加基础科学家和临床医生之间的沟通和合作，并加强职业发展机会，促进从实习生到独立科学家的过渡。我们建议培训三名博士前研究员、三名博士后研究员和两名暑期实习生。这比我们目前的水平增加了一名博士后研究员和一名实习生。博士后的增加是致力于扩大我们的培训池，以医学博士。此次扩展旨在促进我们研究计划的翻译部分，并增加所有学员的临床接触。增加一名暑期实习生是对我们自上次续约以来开发的非常成功的暑期项目的认可。所有的博士前培训生将从生物医学和机械工程系的申请人中挑选出来，其中有一个丰富的和不断增长的申请人库。博士后研究员也可以通过生理学，物理治疗和人类运动科学，物理医学和康复部门联合我们的计划。后一个部门也将通过现有的临床奖学金计划提供研究理疗师的来源。所有学员，无论级别如何，都将在我们的计划中完成2年的培训。通过将所提出的创新与我们已经实施的成功实践相结合，我们希望通过培养下一代跨学科领导者，继续推进康复医学的科学和实践。 公共卫生相关性：该提案旨在为我们的病理生理学和神经功能障碍康复（PRND）培训计划的第五周期提供资金。具体目标是培养康复科学家，他们了解神经残疾人面临的广泛问题，并拥有临床，科学和定量技能，以减轻这一不断增长的人口的负担。

DESCRIPTION (provided by applicant): This proposal seeks funding for the fifth cycle of our training program in Pathophysiology and Rehabilitation of Neural Dysfunction (PRND). The program is directed by Dr. Eric Perreault, PhD, and co-Directed by Drs. CJ Heckman, PhD and Todd Kuiken, MD, PhD. Trainees will be guided by a total of 23 highly collaborative mentors spanning the range from cellular neurophysiology, to engineering, to clinical medicine, all with an emphasis on rehabilitation from neural dysfunction. The specific objectives of our program are to train rehabilitation scientists who understand the broad spectrum of problems confronting people with neurologic disabilities, and who possess the clinical, scientific and quantitative skils to alleviate the burden on this growing population. The program is based at Northwestern University, in close collaboration with the Rehabilitation Institute of Chicago. These two institutions have a long, collaborative history of cutting-edge rehabilitation research, to which or program has contributed. During our first 4 cycles of funding, the program has directly supported 34 pre- doctoral fellows, 24 postdoctoral fellows, and 5 summer interns. Many of these trainees are now established leaders in the field of rehabilitation medicine. In this renewal application, w seek to build on our past achievements and increase our impact through innovations designed to formalize the clinical component of our training program, increase the communication and collaboration between basic scientists and clinicians, and strengthen the career development opportunities that facilitate the transition from trainee to independent scientist. We propose to train three predoctoral fellows, three postdoctoral fellows and two summer interns. This is an in- crease of one postdoctoral fellow and one intern over our current levels. The postdoctoral increase is dedicated to expanding our training pool to MDs. This expansion is aimed at facilitating the translational component of our research program, and increasing the clinical exposure of all trainees. The increase in one summer intern is in acknowledgment of the highly successful summer program we have developed since our last renewal. All predoctoral trainees will be selected from applicants in the departments of Biomedical and Mechanical Engineering, from which there is an abundant and growing applicant pool. Postdoctoral fellows may also joint our program through the departments of Physiology, Physical Therapy and Human Movement Sciences, and Physical Medicine and Rehabilitation. This latter department also will provide a source of research physiatrists through the existing clinical fellowship program. All trainees, regardless of level, will complete 2 year of training in our program. By integrating the proposed innovations with the successful practices we already have in place, we expect to continue advancing the science and practice of rehabilitation medicine by training the next generation of interdisciplinary leaders. PUBLIC HEALTH RELEVANCE: This proposal seeks funding for the fifth cycle of our training program in Pathophysiology and Rehabilitation of Neural Dysfunction (PRND). The specific objectives are to train rehabilitation scientists who understand the broad spectrum of problems confronting people with neurologic disabilities, and who possess the clinical, scientific and quantitative skills to alleviate the burden on this growing population.