TRAINING IN MOLECULAR DERMATOLOGY AND CUTANEOUS CONNECTIVE TISSUE DISEASES

描述(由申请人提供)：这是一个新的申请，请求支持NRSA机构研究培训补助金(T32)，“分子皮肤病和皮肤结缔组织疾病培训”。该计划的总体目标是为以下人员提供严格的科学培训：(A)积极进取的医生，致力于在皮肤科长期住院医师培训的背景下成为下一代医生/科学家的成员；(B)高资质博士，致力于进行适用于皮肤病和结缔组织疾病的基础科学研究；(C)在美国皮肤病委员会的指导下寻求临床转化研究培训的皮肤科住院医师。该计划旨在提供(A)密切监督的密集实验室研究培训，强调应用最先进的分子生物学、细胞生物学、人类遗传学和生物化学方法来研究影响皮肤结缔组织的疾病的病因、发病机制和治疗，和/或(B)在美国国立卫生研究院赞助的人类临床研究计划(K30)的背景下进行结构化的转化性临床研究培训。被该项目录取的成功候选人是根据他们在生物医学研究方面的非凡承诺、对皮肤生物学的浓厚兴趣以及对学术医学的坚定承诺而被选中的。跨学科和跨部门的导师团体代表了杰斐逊医学院教职员工的广泛科学专业知识，核心教员来自皮肤病和皮肤生物学系。该教员在结缔组织研究方面长期致力于培训医生/科学家和博士，并在招聘代表性不足的少数群体方面做出了坚定的承诺，特别是妇女和西班牙裔个人。该计划的教员过去一直非常成功地培训留在生物化学、分子和细胞生物学以及分子遗传学学术领域的个人，因为他们与皮肤病、皮肤生物学和结缔组织疾病有关；之前由教员培训的几名研究员仍然是全职院士，其中许多人在皮肤病和其他临床学科担任领导职务。培训计划将各种培训活动整合为一个统一的计划，重点是皮肤病和结缔组织疾病的研究。所提供的培训机会具有统一的目标，即使受训者准备好将最先进的分子生物学、遗传学、细胞生物学、生物化学和人类临床研究方法应用于研究影响结缔组织的广泛条件。在课程结束时，学员将准备获得学术任命，并从事医生/科学家、临床研究人员或博士的职业生涯，能够在皮肤病和结缔组织疾病相关领域建立独立的研究项目。

DESCRIPTION (provided by applicant): This is a new application requesting support for a NRSA Institutional Research Training Grant (T32), "Training in Molecular Dermatology and Cutaneous Connective Tissue Diseases". The general objective of this Program is to provide rigorous scientific training to: (a) highly motivated physicians committed to become members of the next generation of physician/scientists in the context of extended residency training in dermatology; (b) highly qualified Ph.D.s committed to conduct basic science research applicable to dermatology and connective tissue diseases; and (c) dermatology residents who seek training in clinical translational research under the guidelines of the American Board of Dermatology. The program is designed to provide (a) closely supervised, intensive laboratory research training emphasizing the application of state-of-the-art methods of Molecular Biology, Cell Biology, Human Genetics and Biochemistry towards the investigation of the etiology, pathogenesis, and treatment of diseases affecting cutaneous connective tissues, and/or (b) structured translational clinical research training in the context of a NIH-sponsored program in Human Clinical Investigation (K30). The successful candidates admitted to the program are selected on the basis of their exceptional promise in biomedical research, strong interest in cutaneous biology, and the firm commitment to academic medicine. The interdisciplinary and interdepartmental body of mentors represents the broad scientific expertise of the faculty of Jefferson Medical College, the core faculty members being from the Department of Dermatology and Cutaneous Biology. This faculty has long-term commitment and established track record in training physician/scientists and Ph.D.s in connective tissue research, with strong commitment to the recruitment of underrepresented minorities, particularly women and Hispanic individuals. The program faculty has been in the past highly successful in training individuals who have remained in the academic spheres of biochemistry, molecular and cellular biology, and molecular genetics, as they relate to dermatology, cutaneous biology and connective tissue diseases; several previous fellows trained by the faculty have remained as full- time academicians, many of them in leadership positions in dermatology and other clinical disciplines. The training program consolidates various training activities into a unified program which will focus on the study of skin disorders and connective tissue diseases. The training opportunities offered have the unifying goal of preparing the trainees in the application of the most advanced methods of molecular biology, genetics, cell biology, biochemistry, and human clinical investigation to the study of broad spectrum of conditions affecting the connective tissues. At the completion of the program, trainees will be prepared to obtain academic appointments and to pursue careers as physician/scientists, clinical investigators or as Ph.D.s capable of establishing independent research programs in the areas relevant to dermatology and connective tissue diseases.