Behavioral Interventions and Long Term Outcomes in Juvenile Fibromyalgia Syndrome

描述(申请人提供)：这个职业生涯中期研究员奖申请的具体目标是：1)成功实施正在进行的针对青少年纤维肌痛的随机临床试验；2)进行前瞻性纵向研究以确定青少年纤维肌痛患者的长期预后；3)使用候选人正在进行的和计划中的儿科疼痛研究计划研究来培训儿科疼痛研究方面的博士后研究员和初级教师。候选人的方案研究重点是患有慢性疼痛的儿童和青少年的身体和心理社会功能，重点是青少年纤维肌痛综合症--一种了解很少的慢性疼痛状况，没有循证治疗。该研究计划包括两个项目：NIAMS资助的多点随机临床试验(ROL)，以测试认知行为治疗青少年纤维肌痛的疗效，以及青少年纤维肌痛结果的纵向研究。这位候选人未来的计划是利用当前项目的发现来开发治疗青少年纤维肌痛和其他儿科疼痛状况的最有效的疗法。指导计划是在儿科慢性疼痛的临床干预和结果研究领域培训未来的临床研究人员。候选人的计划包括1)由目前资助的两项临床试验(青少年纤维肌痛和慢性儿科头痛的治疗)支持的对博士后研究员的个性化指导，拟议的青少年纤维肌痛纵向研究，以及其他正在进行的儿科疼痛临床和翻译研究研究2)指导研究员制定他们自己的独立研究建议，以及3)研究员参与关于手稿和拨款撰写、临床研究方法和负责任的人体研究的既定教学计划。辛辛那提儿童医院为这一奖项提供了一个理想的环境，因为它为以患者为导向的研究提供了强有力的机构支持，存在获奖的慢性疼痛计划，分部数据核心对方法学和数据管理问题的支持，以及该机构致力于为儿科患者“改变结果”。相关性(参见说明)：这项研究满足了更好地了解和治疗儿童慢性疼痛(青少年纤维肌痛)这一公共卫生目标，以及培训下一代临床医生-科学家在儿科疼痛临床和转化性研究方面的目标。

DESCRIPTION (provided by applicant): The Specific Aims of this Midcareer Investigator Award application are to 1) successfully implement an ongoing randomized clinical trial in juvenile fibromyalgia 2) perform a prospective longitudinal study to determine long term prognosis of pediatric patients with juvenile fibromyalgia, and 3) use the candidate's ongoing and planned studies in the Pediatric Pain Research Program to train post-doctoral fellows and junior faculty in pediatric pain research. The Candidate's programmatic line of research focuses on physical and psychosocial functioning of children and adolescents with chronic pain, with an emphasis on juvenile fibromyalgia syndrome - a very poorly understood chronic pain condition for which there is no evidence- based treatment. The Research Plan includes two projects: a NIAMS funded multi-site randomized clinical trial (ROl) to test the efficacy of cognitive behavioral treatment for children and adolescents with juvenile fibromyalgia, and a longitudinal study of outcomes in juvenile fibromyalgia. The candidate's future plans are to use findings from current projects to develop the most effective treatments for juvenile fibromyalgia and other pediatric pain conditions. The Mentoring Plan is to train future clinical investigators in the field of clinical interventions and outcomes research in pediatric chronic pain. The candidate's plan consists of 1) individualized mentoring of postdoctoral fellows supported by two currently funded clinical trials (Treatment of Juvenile Fibromyalgia, and Chronic Pediatric Headaches), the proposed longitudinal study in juvenile fibromyalgia, and other ongoing clinical and translational research studies in pediatric pain 2) mentoring of fellows to develop their own independent research proposals and 3) participation of fellows in established didactic programs on manuscript and grant writing, clinical research methodology and responsible conduct of human research. Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research, presence of an award winning chronic pain program, support from the Divisional Data Core for methodological and data management issues, and a commitment of the institution to "change the outcomes" for pediatric patients. RELEVANCE (See Instructions): This study meets the public health goal of better understanding and treating a poorly understood chronic pain condition of childhood (juvenile fibromyalgia) along with the goal of training the next generation of clinician-scientists in clinical and translational research in pediatric pain.