Archiving Datasets of the Brain & Aging Research Program

描述(由申请人提供)：获取包含表型、生物、心理和社会信息的综合数据集是昂贵和劳动密集型的，但对于研究衰老和相关疾病是必要的。脑与老龄化研究项目(BARP，澳大利亚新南威尔士大学)在过去十年中投入了大量资源来建立队列，并收集关于澳大利亚老年人的丰富的多方面纵向数据集。这些队列包括社区居住的非痴呆者、双胞胎、百岁老人/近百岁老人和中风幸存者，数据范围从生化、遗传和医学成像数据到纵向收集的详细神经心理、行为和人口统计信息。目前的项目建议重新格式化这些广泛的数据库，以便向公共领域发布，以便世界各地的研究人员可以公开分享和分析这些数据。这将有助于研究老龄化和与年龄相关的脑部疾病的国际努力。BARP数据库包括4项纵向队列研究：1.记忆与老龄化研究(MAS)：2005年开始对澳大利亚悉尼东郊1000多名社区非痴呆者进行的研究，每年从参与者那里收集信息，每两年进行一次详细评估，包括神经成像、遗传学和蛋白质组学。它的主要目的是确定与老年和痴呆症认知能力下降有关的风险和保护因素(n=1000+；每个评估有2000+个变量)。2.更古老的澳大利亚双胞胎研究(OATS)：一项始于2007年的对300多对澳大利亚同卵和异卵双胞胎的研究，每年收集信息。它的目的是确定遗传和环境因素对认知能力下降和健康老龄化的相对影响(n=600；每个评估2000+个变量)。3.悉尼百岁老人研究(SCS)：一项针对95岁以上老年人的研究，始于2008年，每6个月从参与者那里收集信息(最多3个评估)。它的目的是比较认知能力下降和健康老龄化与异常长寿的关系，并调查发病率压缩理论(n=250+；每项评估1000+变量)所描述的所谓的“超级健康”人类表型。4.悉尼中风研究(SSS)：一项对中风患者和健康对照组的研究，在中风后3-6个月，然后在1年、3年和5年后进行评估(n=200中风；100名对照；每次评估有1000多个变量)。所有4项研究都收集了认知表型(例如痴呆症/MCI+亚型/健康)、神经认知评估、心理社会问卷、病史+检查、用药情况、神经成像、血液化学、蛋白质组学和遗传学/基因组学(没有蛋白质组学或遗传学对SSS)的数据。所有的研究都是纵向收集数据的，因此BARP数据库对世界各地的研究人员来说是一个真正丰富和有价值的潜在数据来源。 公共卫生相关性：对老龄化和与年龄相关的神经精神障碍的调查取决于是否有经过纵向评估的具有良好特征的老年人队列。新南威尔士大学的大脑和老龄化研究计划已经建立了一些具有广泛文献资料的纵向队列。这项提议将公开发布四个纵向数据库，其中包含超过2000名老年人的数据(每个数据集最多2000个变量)，范围从健康人到痴呆症患者，包括四个队列：社区居住的老年人(70-90岁)、老年双胞胎(65岁)、百岁/近百岁老人和中风患者。这些数据包括神经精神病学和医学评估、神经成像、遗传学和蛋白质组学，因此这些队列将为世界各地的研究人员调查老龄化和相关疾病提供独特的国际资源。

DESCRIPTION (provided by applicant): The acquisition of comprehensive datasets containing phenotypic, biological, psychological and social information is expensive and labor-intensive but is necessary for the investigation of aging and related disorders. The Brain and Ageing Research Program ('BARP', University of New South Wales, Australia) has committed substantial resources over the last decade to establish cohorts and collect rich multi-faceted longitudinal datasets on older individuals in Australia. The cohorts include community-dwelling non-demented individuals, twin pairs, centenarians/ near-centenarians and stroke survivors, and the data ranging from biochemical, genetic & medical imaging data through to detailed neuropsychological, behavioral and demographic information collected longitudinally over multiple waves. The current project proposes to re-format these extensive databases for release into the public domain so that the data can be shared openly and analyzed by researchers around the world. This will contribute to the international effort to investigate aging and age-related brain diseases. The BARP databases comprise 4 longitudinal cohort studies: 1. The Memory & Ageing Study (MAS): a study of 1000+ community-based non-demented individuals from the Eastern suburbs of Sydney (Australia) which began in 2005 and collects information from its participants on an annual basis, with detailed assessments every two years, including neuroimaging, genetics and proteomics. Its primary aim is to determine the risk and protective factors in relation to cognitive decline in aging and dementia (n = 1000+; 2000+ variables per assessment). 2. The Older Australian Twins Study (OATS): a study of 300+ Australian monozygotic and dizygotic twin pairs which began in 2007 and collects information on an annual basis. It aims to determine the relative impact of genetics vs. environmental factors in relation to both cognitive decline and healthy aging (n = 600; 2000+ variables per assessment). 3. The Sydney Centenarian Study (SCS): a study of individuals aged 95+ years of age which began in 2008 and collects information from its participants on a 6 monthly basis (max. 3 assessments). It aims to compare cognitive decline and healthy aging in relation to exceptional longevity, as well as investigating the so-called 'super healthy' human phenotype described by compression-of-morbidity theories (n = 250+; 1000+ variables per assessment). 4. The Sydney Stroke Study (SSS): a study of stroke patients and healthy controls assessed 3-6 months after the stroke then 1, 3 and 5 years later (n = 200 stroke; 100 controls; 1000+ variables per assessment). All 4 studies collected data on cognitive phenotypes (e.g. dementia/MCI+subtypes/healthy), neurocognitive assessment, psychosocial questionnaires, medical history + exam, medication use, neuroimaging, blood chemistry, proteomics and genetics/genomics (no proteomics or genetics for SSS). All studies collect data longitudinally and thus the BARP databases represent a truly rich and valuable potential data source for researchers worldwide. PUBLIC HEALTH RELEVANCE: The investigation of aging and age-related neuropsychiatric disorders is dependent upon the availability of well-characterized cohorts of aging individuals who have been assessed longitudinally. The Brain and Ageing Research Program at the University of New South Wales has established a number of longitudinal cohorts with extensive documentation. This proposal will see the public release of four longitudinal databases containing data (up to 2000+ variables per dataset) on over 2000 elderly individuals ranging from the healthy to those with dementia, and inclusive of four cohorts: community dwelling elderly (aged 70-90 years), elderly twins (aged >65 years), centenarians/ near-centenarians and stroke sufferers. The data include neuropsychiatric and medical assessments, neuroimaging, genetics and proteomics, and these cohorts will therefore provide a unique international resource for the investigation of ageing and associated disorders by researchers world-wide.