COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settings

COSMIC：一个国际联盟，旨在识别不同种族群体和地理环境中认知衰老和痴呆的风险和保护因素以及生物标志物

• 批准号: 9421565
• 负责人: Perminder S SACHDEV
• 金额: $ 257.36万
• 依托单位: UNIVERSITY OF NEW SOUTH WALES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9421565
• 关键词: Address; Age; Aging; Alzheimer' s Disease; Applications Grants; Biological Markers; Canada; Cognitive aging; Cohort Studies; Collaborations; Country; Data; Databases; Dementia; Demographic Factors; Development; Diagnosis; Diagnostic; Disease; Elderly; Ensure; Epidemiology; Geographic Locations; Geography; Health; Health Care Costs; Healthcare Systems; Impaired cognition; Incidence; Individual; International; Internships; Longitudinal prospective study; Memory; Meta-Analysis; Methodology; Nomads; Older Population; Outcome; Paper; Pattern; Population; Population Heterogeneity; Population Study; Prevalence; Prevention; Prevention strategy; Publishing; Race; Reporting; Research; Resources; Risk; Sample Size; Sampling; Time; Uncertainty; Variant; analytic epidemiology; cohort; data sharing; design; ethnic diversity; health service use; low and middle-income countries; mild cognitive impairment; neurocognitive disorder; novel; population based; prospective; success; systematic review

Project Summary/Abstract The best approach to identify risk and protective factors, and develop early biomarkers, of cognitive decline and dementia in older people is to conduct prospective longitudinal studies of aging in representative cohorts from the population. Many such studies are being conducted around the world. For practical reasons, no single study can have a large enough sample and sufficient power to detect modest-sized effects, or to compare rates, proportions, and antecedents in a large variety of populations. Further, these studies have used disparate methodologies, and even small variations in methodology make results difficult to compare across populations. This grant proposal is to support a consortium – COSMIC (COhort Studies of Memory in International Consortium) – that was established in 2012 and now includes 26 studies from 16 countries in five continents, with a combined sample size of >70,000. The leaders of these studies have agreed to pool de- identified data from these studies. The data harmonization strategy in COSMIC offers the potential to explore both existing and novel research questions by creating a single, large database to help minimize the influence of both study-level (e.g. methodology) and individual level (e.g. demographic) factors, while also enabling these to be explored as potential contributors to differences in results . Other advantages include increased statistical power for detecting effects of modest size, and the inherent replication and enhanced generalizability associated with using heterogeneous samples and methodologies. COSMIC will address many extant questions in the analytical epidemiology of cognitive aging and dementia. It will help examine the rates and patterns of cognitive decline in aging populations in diverse geographical regions and ethno-racial groups, and determine the prevalence and incidence of neurocognitive disorders in these settings. It will inform us which risk and protective factors are universal and others that are specific to certain populations. Novel factors may thereby be identified. Biomarkers of dementia can similarly be examined. The cohorts will permit the examination of decline in individuals who have been diagnosed with dementia, and the burden these disorders pose on the health care systems in different countries. COSMIC is a truly international effort. The rules of engagement have been established and the success of the first two projects has demonstrated its feasibility. This grant proposal is to help ensures its financial viability as it continues to grow to make a lasting impact on the epidemiology of cognitive aging and dementia.

项目总结/文摘

项目成果

Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: the COSMIC consortium.

无痴呆的不同种族人群白质高信号的危险因素和认知相关性：COSMIC 联盟。

• DOI: 10.1101/2023.08.30.23294876
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Lin,Keshuo;Wen,Wei;Lipnicki,DarrenM;Mewton,Louise;Chen,Rory;Du,Jing;Wang,Dadong;Skoog,Ingmar;Sterner,ThereseRydberg;Najar,Jenna;Kim,KiWoong;Han,JiWon;Kim,JunSung;Ng,TzePin;Ho,Roger;Chua,DeniseQianLing;Anstey,Kaarin
• 通讯作者: Anstey,Kaarin