FASEB SRC on "Post-transcriptional Control of Gene Expression: Mechanisms of mRNA

描述(由申请者提供)：本提案请求部分支持在科罗拉多州蒸汽船大度假村举行的为期六天的美国实验生物学学会联合会(FASEB)会议，主题为“基因表达的转录后控制：信使核糖核酸衰退机制(PTCGE)”。FASEB会议是自1998年以来每隔一年举行的一系列会议中的第八次。会议的广泛和长期目标是提高我们目前对转录后控制RNA稳定性和翻译调控正常和疾病状态下基因表达的基本机制的理解。重点是涉及mRNA新陈代谢的转录后事件，但这延伸到转录偶联，以及参与翻译及其控制的因素，包括tRNA和非编码(例如，微)RNA。这次会议的具体目标是召集大约37位代表转录后基因调控关键领域的国际知名演讲者，总共120-140人参加为期6天的会议。该计划将包括9个上午或晚间会议，将广泛讨论以下前沿问题：信使核糖核酸衰变的5‘和3’端控制；信使核糖核酸翻译和衰变的亚细胞定位；RNA结合蛋白和信使核糖核酸命运；信使核糖核酸翻译和衰变之间的耦合；信使核糖核酸质量控制和加工；小分子非编码RNA；疾病中的转录后控制；以及全基因组和生物水平的转录后控制。此外，两个下午晚些时候的小海报会议将使所有参与者能够为这些主题做出贡献，并了解这些主题。在蒸汽船大度假村相对与世隔绝的夏季环境中，自由的午后和深夜时段将刺激来自美国和海外的知名和初级首席调查人员、博士后实习生和研究生之间富有成效的非正式讨论。这项申请的意义在于，这次FASEB会议有一种独特的形式，聚集了几组研究人员，尽管他们有共同的兴趣，但很少有机会作为一个小组见面。一个特别的吸引力是将专注于转录后控制的原核和真核特征的研究人员聚集在一起，以交换信息并激发新的想法。由此产生的讨论和相互促进将有助于确定推动这一领域向前发展的关键领域。此外，阐明转录后基因调控的基本机制对于全面了解人类基因组的组织、功能和进化至关重要。这一应用的健康相关性反映了RNA加工功能障碍在许多遗传性疾病、神经和神经肌肉疾病以及癌症中的广泛参与。 与公共健康相关：这次会议的重点是信使核糖核酸衰变决定在任何给定细胞中产生哪些蛋白质的机制。颠覆这一过程的基因缺陷与神经和神经肌肉疾病以及癌症有关。通过将这种生物问题的不同方面的专家聚集在一起，我们希望激发新的想法，从而导致这些疾病的治疗。

DESCRIPTION (provided by applicant): This proposal requests partial support for a six-day Federation of American Societies of Experimental Biology (FASEB) conference on "Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay (PTCGE)" to be held at the Steamboat Grand Resort in Steamboat, Colorado. The FASEB meeting is the eighth in a series that has been held every other year since 1998. The broad and long-term goal of the Conference is to improve our current understanding of the fundamental mechanisms by which post- transcriptional control of RNA stability and translation regulates gene expression in normal and disease states. The emphasis is on post-transcriptional events involved in the metabolism of mRNA, but this extends to transcriptional coupling, and to factors involved in translation and its control, including tRNA and non-coding (e.g., micro) RNAs. The Specific Aims of this meeting will be to convene approximately 37 internationally known speakers representing key areas of post-transcriptional gene regulation, with a total of 120-140 participants, for a six-day meeting. The program will consist of nine morning or evening sessions that will broadly address cutting-edge issues in: 5' and 3' end control of mRNA decay; subcellular localization of mRNA translation and decay; RNA-binding proteins and mRNA fate; coupling between mRNA translation and decay; mRNA quality control and processing; small non-coding RNAs; post-transcriptional control in disease; and post-transcriptional control at genome-wide and organismal levels. In addition, small poster sessions on two late afternoons will enable all participants to contribute to, and learn about, these topics. Free early-afternoons and late-evening periods in the relatively isolated summer setting of the Steamboat Grand Resort will stimulate productive, informal discussions among established and junior principal investigators, post-doctoral trainees and graduate students from the U.S. and abroad. The significance of this application is that this FASEB meeting has a unique format and brings together sets of researchers who, despite having converging interests, have infrequent opportunities to meet as a group. A particular attraction is to bring together researchers focused on prokaryotic and eukaryotic features of post-transcriptional control to exchange information and stimulate new ideas. The resulting discussions and cross-fertilization will help define critical areas to propel this field forward. In addition, elucidating the basic mechanisms of post-transcriptional gene regulation will be essential to gain a full understanding of the organization, function, and evolution of the human genome. The health relatedness of this application reflects the extensive involvement of RNA-processing dysfunction in numerous genetic diseases, neurological and neuromuscular disorders, and cancer. PUBLIC HEALTH RELEVANCE: This meeting is focused on the mechanisms by which mRNA decay determines which proteins are produced in any given cell. Genetic defects that subvert this process have been linked to neurological and neuromuscular disorders as well as cancer. By bringing together experts in different aspects of this biological problems, we hope to stimulate new ideas that will lead to treatments for these conditions.