2012 Myelin Gordon Research Conference & Gordon Research Seminar

描述(由申请人提供)：通过这份申请，我们请求资助2012年戈登研究研讨会和髓鞘会议，会议将于2012年4月28日至5月5日在意大利巴尔加举行。对三叉神经节和中枢神经系统髓鞘胶质细胞生物学的了解继续快速发展。自从2010年2月在加利福尼亚州文图拉举行的上一次髓鞘GRC会议以来，关于髓鞘胶质细胞的分化、它们与轴突的相互作用以及它们对髓鞘修复的潜力已经出现了重大的新见解。新的促进或抑制髓鞘形成的外在信号已经被识别出来，这可能会指导髓鞘修复的努力。越来越多的人认识到成人中枢神经系统中正在进行的髓鞘形成的程度，以及神经元活动在调节少突胶质细胞发生和分化中的重要性。少突胶质细胞病理学被认为是一系列中枢神经系统疾病的重要组成部分，包括神经退行性疾病，而不仅仅是多发性硬化症。最近的研究表明，免疫系统不仅在髓鞘病理中起作用，而且还可能影响髓鞘的重新形成。第11届戈登会议“髓鞘：生物学和病理生物学”的计划旨在将该领域的领先研究人员聚集在一起，突出这些和其他进展，促进积极的思想交流，并加快研究。我们已作出努力，限制与以往会议发言者的重叠，并突出新出现的议题。髓鞘生物学研究的活力取决于培养下一代研究人员，包括新的独立科学家。为此目的，我们邀请了一些年轻的调查人员在本次会议上以定期和短期会谈的形式发言。高级调查员将以会议主席的身份概述该领域，并发表讲话。将给予适当关注，以确保发言者名册上的性别平衡。为了确保展示最新、最令人兴奋的结果，我们将挑选一些海报主持人进行简短的演讲。为了进一步突出初级研究人员，今年的会议将首次以关于髓鞘的戈登研究研讨会(GRS)开始。我们预计将有50多名年轻研究人员参加，即研究生和博士后研究员。GRS将专注于少突胶质细胞生物学和髓鞘再分化；它将为年轻研究人员提供一个独特的论坛，让他们见面和互动，展示尖端研究，并开展合作。为了进一步鼓励学员参与髓鞘生物学领域的培训，我们将在资金允许的情况下提供旅费和注册津贴。所有与会者将被要求提供口头或海报演示文稿。我们认为，海报会议是促进具有不同专业知识的科学家之间富有成效的互动的关键因素。为了与戈登研究会议的目标保持一致，这种相互作用将推动并加速髓鞘生物学领域的进展。

DESCRIPTION (provided by applicant): With this application, we are requesting support for the 2012 Gordon Research Symposium and Conference on Myelin, to be held in Barga, Italy from April 28 - May 5, 2012. Understanding of the biology of myelinating glia in the PNS and CNS continues to advance rapidly. Since the last Myelin GRC in Ventura, CA in February 2010, major new insights have emerged regarding the differentiation of myelinating glia, their interactions with axons, and their potential for myelin repair. New extrinsic signals that either promote or inhibit myelination have been identified, which may direct efforts at myelin repair. There is a growing appreciation of the extent of ongoing myelination in the adult CNS and of the importance of neuronal activity in regulating the oligodendrocyte genesis and differentiation. Oligodendrocyte pathology is being recognized as an important component in a broad array of CNS diseases, including neurodegenerative disorders, not just multiple sclerosis. Recent studies indicate that the immune system not only contributes to myelin pathology but may also affect remyelination. The program for the 11th Gordon Conference "Myelin: biology and pathobiology" is designed to bring together leading investigators in the field to highlight these and other advances, to foster a vigorous exchange of ideas, and to accelerate research. We have made an effort to limit overlap with speakers from previous meetings and to highlight emerging topics. The vitality of myelin biology research depends on fostering the next generation of investigators, including newly independent scientists. To this end, we have invited a number of young investigators to speak at this meeting, in both regular and short talks. Senior investigators will provide overviews of the field as session chairs and also speak. Appropriate attention will be paid to ensure gender balance among the roster of speakers. To ensure that the latest, most exciting results are presented, some poster presenters will be selected for short talks. To further highlight junior investigators, this year's meeting for the first time will beginwith a Gordon Research Seminar (GRS) on myelin. We expect more than 50 young investigators, i.e. graduate students and post-doctoral fellows, to attend. The GRS will focus on oligodendrocyte biology and remyelination; it will provide a unique forum for young investigators to meet and interact, present cutting edge research, and develop collaborations. To further encourage the participation of trainees in the field of myelin biology, we will offer stipends for travel and registration as funds permit. All attendees will be expected to contribute an oral or poster presentation. We believe that poster sessions are a key element in fostering productive interactions between scientists with different expertise. In keeping with the goals of the Gordon Research Conference, such interactions will provide impetus and accelerate progress in the field of myelin biology.