Chemistry and Mechanisms for Environmental Stress

描述(由申请人提供)：本申请请求支持2013年9月8日星期日至2013年9月11日星期三在印第安纳波利斯举行的第246次全国会议和博览会上对美国化学学会化学毒理学分部的规划。本次ACS会议的一个独特之处是全国会议的广泛主题“化学在运动”，它将所有ACS部门的重点活动联系在一起。美国化学毒理学协会化学毒理学分部的使命是促进对导致疾病过程的化学机制以及环境制剂、生物材料、药物和内源性化学物质的毒性的了解。该司综合了化学、化学生物学、结构生物学、毒理学、环境卫生科学和疾病机制方面的工作。围绕“化学和环境压力的机制”这一中心主题，计划举办三个相互关联的研讨会，其中包括由知名和新兴科学家组成的不同团体的特邀演讲。请求提供支助的三个专题讨论会与NIEHS的使命特别相关。第一个题为“毒理学中的代谢组学”，重点介绍了用于系统分析的全球图谱技术和数据集成工具的实施情况。第二篇题为《金属毒性的化学和生物学》，重点介绍金属-生物分子相互作用及其系统效应的新机制研究。第三次专题讨论会题为“替代燃料的毒理学”，重点讨论吸入毒性机制和致癌机制。提供的论文会议和青年调查人员专题讨论会为正在接受培训的青年科学家提供机会，介绍他们的主要贡献，并从资深专家那里获得批判性反馈。其他亮点包括克里斯托弗·奥斯汀博士(国家翻译科学推进中心主任)的主旨演讲和两个备受瞩目的奖项研讨会(创始人奖和毒理学化学研究青年研究员奖)。这些会议(由非联邦基金支持)将进一步加强一个强大的整体计划，并为不同的参与者提供突出的代表，展示环境暴露和疾病的化学和生物学方面的当前工作。

DESCRIPTION (provided by applicant): This application requests support for programming of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 246th National Meeting and Exposition in Indianapolis, IN from Sunday, September 8, 2013 to Wednesday, September 11, 2013. A unique feature of this ACS meeting is the broad theme of the national meeting, "Chemistry in Motion", which aligns highlighted events across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes and the toxicity of environmental agents, biomaterials, drugs and endogenous chemicals. The Division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. Three interrelated symposia are planned around the central theme "Chemistry and Mechanisms of Environmental Stress" and include invited talks by a diverse group of leading established and emerging scientists. The three symposia for which support is requested have especially strong relevance to the mission of the NIEHS. The first is entitled "Metabolomics in Toxicology" and highlights the implementation of global profiling technologies and data integration tools for systems analysis. The second is entitled "Chemistry and Biology of Metal Toxicity" and focuses on new mechanistic studies of metal-biomolecule interactions and their systemic effects. The third symposium session is entitled "Toxicology of Alternative Fuels" and focuses on inhalation toxicity mechanisms and carcinogenesis. A proffered paper session and a Young Investigators Symposium offer opportunities for young scientists in training to present their primary contributions and receive critical feedback from senior experts. Other highlights are a keynote lecture by Dr. Christopher Austin (Director of the National Center for Advancing Translational Sciences) and two high profile award symposia (the Founders Award and the Chemical Research in Toxicology Young Investigator Award). These sessions (supported by non-federal funds) will further enhance a strong overall program and provide diverse participants an outstanding representation of current work in the chemistry and biology of environmental exposures and disease.