Comp C-Urological Managment of Newborns with Spina Bifida

描述(申请人提供)：脊柱裂是一种主要的先天性脊髓及相关脊椎畸形。在美国，它的发病率约为每1000名新生儿中就有一名，目前临床流行率超过7万人。它是最常见的导致多器官系统严重残疾的出生缺陷。脊髓损伤对神经系统、骨科和泌尿系统有许多有害的影响。脊柱裂婴儿的泌尿学评估从出生就开始了。尽管人们普遍同意对婴儿进行早期泌尿外科管理的重要性，但对于什么形式的管理是最合适的，多年来一直存在重大争议。这项研究的目的是，利用一个定义明确的最佳做法协议，在5个月内进行一项多机构研究 几年的时间来确定对出生时患有脊柱裂的婴儿进行最合适的泌尿外科治疗。这项研究的目的也是评估研究结束时的许多功能结果测量，包括肾功能和膀胱动力学的具体测量。

DESCRIPTION (provided by applicant): Spina bifida is a major congenital anomaly of the spinal cord and the associated vertebrae. It has an incidence of roughly 1 per 1000 births and a current clinical prevalence of greater than 70,000 people in the United States. It is the most common birth defect that results in severe disability of multiple organ systems. The spinal cord lesion has numerous deleterious effects on the neurologic, orthopedic and urologic systems. Urological evaluation of infants with spina bifida begins at birth. Despite universal agreement on the importance of early urological management of the infant, for some years there has been a major controversy as to what form of management is most appropriate. The aim of this research is, utilizing a well defined best practices protocol, to conduct a multi-institutional study over 5 years to determine the most appropriate form of urologic management in infants born with spina bifida. The purpose of the research is also to assess numerous functional outcome measures at the end of the study period including specific measurements of renal function and bladder dynamics.