Workshop on Techniques in Modeling Human Cancer in Mice

项目摘要/摘要 癌症是一组基因复杂、生物异质性的疾病。它已经变得越来越多 显然，实验室小鼠，人类最好的基因定义的实验模式生物， 为理解遗传基础和潜在的生物学提供了一个快速发展的重要机会 癌症的威胁。我们课程的总体目标是“在小鼠身上建立人类癌症模型的技术研讨会”，目的是 培训一小群年轻科学家(博士后、博士后实习生、新研究员)使用 在遗传学上，实验室小鼠被定义为遗传工具，用于询问基因功能和基因的作用 癌症生物学中的遗传学。完成这门课程的学生将获得有关如何 描述和分析特定的小鼠癌症模型。选择的模型将反映几个器官部位 包括结肠、前列腺、乳腺、肺、皮肤、血液和脑。这门课程将包括关于 上午介绍特定的器官部位和与这些器官相关的癌症的特征 地点，然后是密集的实验室课程，学生将在其中获得实践经验 相关鼠标模型的操作和分析。会议将包括固定细胞成像和活细胞成像 技术、细胞学、肿瘤植入的外科方法和病理学。 这些目标将通过向16名被选中的年轻调查人员提供为期10天的强化课程来实现 他们杰出的研究潜力。他们将与一群著名的老鼠遗传学家和癌症专家互动 来自杰克逊实验室和其他著名机构的生物学家。班级人数将保持不变 故意很小，以实现理想的师生互动水平，并允许广泛的 对学员进行实验室培训和实习。该课程将于每年10月份举行。 在公海，杰克逊实验室的住宅海滨会议设施。讲座、讨论、 工作坊和演示将在上午、下午和晚上举行，总共约72人 几个小时的授课和动手训练。我们要求在此应用程序中提供整整五年的支持。 杰克逊实验室是NCI指定的基础研究癌症中心，拥有悠久的 举办高级课程和科学会议。

PROJECT SUMMARY/ABSTRACT Cancer is a genetically complex and biologically heterogeneous group of disorders. It has become increasingly clear that the laboratory mouse, the best genetically defined experimental model organism for humans, presents a major opportunity for rapid advancement in understanding the genetic basis and underlying biology of cancer. The overall goal for our course, "Workshop on Techniques in Modeling Human Cancer in Mice", is to train a small group of young scientists (predoctoral, postdoctoral trainees, new investigators) in the use of genetically defined laboratory mice as genetic tools for asking questions about gene function and the role of genetics in the biology of cancer. Students completing the course will acquire a practical knowledge of how to characterize and analyze specific mouse cancer models. The models chosen will reflect several organ sites including colon, prostate, mammary, lung, skin, blood and brain. The course will consist of didactic lectures in the morning to introduce particular organ sites and the characteristics of cancers associated with those organ sites, followed by intensive laboratory sessions whereby students will gain hands on experience in the manipulation and analysis of relevant mouse models. Sessions will include fixed and live cell imaging techniques, cytometry, surgical approaches to the implantation of tumors, and pathology. These Aims will be accomplished by offering an intensive 10-day course to 16 young investigators chosen for their outstanding research potential. They will interact with a group of prominent mouse geneticists and cancer biologists both from The Jackson Laboratory and other prominent institutions. The size of the class will be kept deliberately small in order to achieve a desirable level of student-faculty interaction and to permit extensive laboratory training and practice for the students. The course will be held annually during the month of October at Highseas, The Jackson Laboratory's residential oceanfront conference facility. Lectures, discussions, workshops, and demonstrations will be held morning, afternoon, and evening for a total of approximately 72 hours of didactic and hands-on training. We are asking for a full five years of support in this application. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of hosting advanced courses and scientific meetings.