Multimodal imaging in frontotemporal degeneration

描述(申请人提供)：申请这笔资金是为了支持行为神经学家Howard Rosen博士，他的研究重点是使用临床和实验行为评估和成像对非典型神经退行性疾病，特别是额颞叶变性(FTLD)进行早期识别、更好的表征和纵向跟踪。罗森博士对指导有着长期的兴趣。这项提议的目标是1)支持罗森博士有时间为越来越多的临床研究人员提供指导，2)支持他有时间增强他作为研究人员的技能，以及3) 提高他进行以患者为中心的研究(POR)的能力，并将这些技能传授给他的导师。为了实现这些目标，他将增强自己的统计分析技能，作为导师增加自我发展的努力，并制定更正式的指导计划。此外，这笔赠款将特别有助于支持罗森博士的新目标，包括提高他对老年精神病学评估的理解，将这些方法引入他的研究，并接触更多对精神症状感兴趣的受训者。对罗森博士和他的受训者的培训将通过选定的课程和研究活动来完成，包括数据分析和手稿准备，使用罗森博士正在进行的项目的数据，包括额颞叶变性神经成像计划，以及正在进行的研究痴呆症患者自我意识受损的认知和情感基础的项目。由于他在多模式脑成像以及情绪研究中的心理生理学和行为方法论方面的经验，罗森博士拥有独特的专业知识，可以让具有神经学、精神病学和心理学背景的受训者受益。此外，Rosen博士还提出了一个新项目，该项目将DSM结构化临床访谈(SCID)添加到对受导致FTLD(f-FTLD)突变影响的家庭成员的临床评估中。该项目的目的是量化早期f-FTLD的传统精神症状的频率，并评估精神病学诊断在预测一年以上皮质变薄方面的价值。这项研究将更好地描述f-FTLD的早期临床表现，并为散发性FTLD发展之前的精神症状提供指导，以便在未来的研究中进行研究。

DESCRIPTION (provided by applicant): This grant is being requested to support Dr. Howard Rosen, a behavioral neurologist whose research has focused on early recognition, better characterization and longitudinal tracking of atypical neurodegenerative diseases, in particular frontotemporal lobar degeneration (FTLD), using clinical and experimental behavioral assessment and imaging. Dr. Rosen has a longstanding interest in mentoring. The goals of this proposal are 1) to support time for Dr. Rosen to provide mentoring to a growing number of clinical researchers, 2) to support time for him to augment his skills as an investigator and 3) to increase his ability to conduct patient oriented research (POR) and to impart these skills to his mentees. To accomplish these goals he will augment his skills in statistical analysis, increase his efforts in self-development as a mentor and develop a more formal mentoring program. In addition, this grant will be particularly instrumental in supporting Dr. Rosen's new goals, which include improving his understanding of geriatric psychiatric assessment, introducing these approaches into his research and reaching out to more trainees interested in psychiatric symptoms. Training for both Dr. Rosen and his mentees will be accomplished through selected coursework and research activities including data analysis and manuscript preparation, using the data from Dr. Rosen's ongoing projects, including the Frontotemporal Lobar Degeneration Neuroimaging Initiative, and an ongoing project to study the cognitive and emotional basis of impaired self-awareness in dementia. Because of his experience in both multimodal brain imaging and psychophysiological and behavioral methodology from emotions research, Dr. Rosen has unique expertise that can benefit trainees with neurology, psychiatry and psychology backgrounds. In addition, Dr. Rosen is proposing a new project, which will add the Structured Clinical Interview for DSM (SCID) to the clinical assessment of members of families affected by mutations that cause FTLD (f-FTLD). The aims of the project are to quantify the frequency of traditional psychiatric syndromes in early f-FTLD, and to assess value of psychiatric diagnosis in predicting the rate of cortical thinning over one year. The study will provide better characterization of the early clinical presentation of f-FTLD and give guidance about the psychiatric symptoms that may precede the development of sporadic FTLD, which can then be investigated in future studies.