PS11-003 Minority AIDS Research Initiative

描述（由申请人提供）：拟议的研究旨在解决西班牙裔和非西班牙裔白人之间的健康差异，特别是与西班牙裔青少年的艾滋病毒和吸毒有关。这一目标将通过两个目标来实现：第一目标是发展面对面家庭联合干预的互联网版本（以下称为基于互联网的家庭联合干预）；AIM II是评估基于互联网的家庭教育相对于面对面家庭教育和社区实践控制条件在预防迈阿密戴德县社区西班牙裔青少年无保护的性行为和吸毒方面的效果。从三所高中招募的270名西班牙裔青少年将使用瓮设计随机分配到三种条件之一：基于互联网的家庭培训，面对面的家庭培训或社区实践。在两项随机临床试验中，面对面家庭干预（familas Unidas）是一项针对西班牙裔的、以家庭为中心的干预措施，相对于对照组，在预防青少年无保护的性行为和吸毒方面效果显著（Pantin et al., 2009; Prado et al., 2007）。分层线性模型（HLM）将用于检验：（H1）随着时间的推移，基于互联网的家庭和面对面的家庭在预防青少年无保护的性行为方面比社区实践控制更有效；（H2）长期来看，基于互联网的家庭网络和面对面的家庭网络在预防青少年吸毒方面比社区实践控制更有效；（H3）随着时间的推移，基于互联网的家庭联盟比面对面的家庭联盟在预防青少年无保护的性行为方面更有效；（H4）随着时间的推移，基于互联网的家庭联盟将比面对面的家庭联盟在预防青少年吸毒方面更有效。此外，HLM将用于确定（H1a）基于互联网的家庭和面对面的家庭对青少年无保护的性行为的影响是否会部分被家庭功能介导；（H2a）家庭网络和面对面家庭网络对青少年吸毒的影响会部分被家庭功能所调节；（H3a）互联网家庭联盟对无保护性行为的影响将部分由参与率调节；（H4a）互联网家庭联盟对青少年药物使用的影响将部分由参与率调节。

DESCRIPTION (provided by applicant): The proposed study aims to address health disparities between Hispanic and non-Hispanic whites, particularly as it relates to HIV and drug use in Hispanic adolescents. This goal will be accomplished by two aims: AIM I is to develop an Internet-based version of the face-to-face Familias Unidas intervention (hereafter referred to as Internet-Based Familias Unidas); and AIM II is to evaluate the efficacy of Internet-Based Familias Unidas, relative to both face-to-face Familias Unidas and a community practice control condition, in preventing unprotected sexual behavior and drug use in a community sample of Hispanic adolescents living in Miami-Dade County. 270 Hispanic adolescents recruited from three high schools will be randomized using an urn design to one of three conditions: Internet-Based Familias Unidas, face-to-face Familias Unidas or Community Practice. Face-to-face Familias Unidas, a Hispanic-specific, family- centered intervention, has been found efficacious, relative to control conditions, in preventing adolescent unprotected sexual behavior and drug use in two randomized clinical trials (Pantin et al., 2009; Prado et al., 2007). Hierarchical Linear Modeling (HLM) will be used to test: (H1) Internet-Based Familias Unidas and face-to-face Familias Unidas will be more efficacious than Community Practice Control in preventing adolescent unprotected sexual behavior over time; (H2) Internet-Based Familias Unidas and face-to-face Familias Unidas will be more efficacious than Community Practice Control in preventing adolescent drug use over time; (H3) Internet-Based Familias Unidas will be more efficacious than face-to-face Familias Unidas in preventing adolescent unprotected sexual behavior over time; and (H4) Internet-Based Familias Unidas will be more efficacious than face-to-face Familias Unidas in preventing adolescent drug use over time. Additionally HLM will be used to determine whether (H1a) the effect of Internet-Based Familias Unidas and face-to-face Familias Unidas on adolescent unprotected sexual behavior will be partially mediated by family functioning; (H2a) the effect of Internet-Based Familias Unidas and face-to- face Familias Unidas on adolescent drug use will be partially mediated by family functioning; (H3a) the effect of Internet-Based Familias Unidas on unprotected sexual behavior will be partially mediated by participation rates; and (H4a) the effect of Internet-Based Familias Unidas on adolescent drug use will be partially mediated by participation rates.