Cardiovasology

描述（由申请人提供）：梅奥诊所的“心血管学”博士后培养计划，在这次更新中，要求继续支持36至40年。经过四十年的指导职业发展，该计划已经实现了培养医生和科学家在心血管医学和生物学方面的独立研究事业的使命。学员获得了严格的科学能力，在生产力方面表现出色，在研究支持方面建立了良好的记录，并获得了学术安排，为国家多样化的劳动力做出了贡献。取得的成就包括强大的招聘和保留，与NIH资助的优秀教师的互动指导，强大的基础设施和合作环境确保了竞争性职业的启动。更新跨越了科学教育和实践的交叉点，以最好地装备下一代研究者。该项目以最高的教育标准和尖端的技术平台为基础，根据每个学员的背景和职业道路进行定制，同时扩大他们的兴趣和能力，追求不断发展的科学进步。心力衰竭是中心主题，其重点是将从临床到临床再到人群的转变，反映了全国发病率和死亡率的趋势。该项目通过实施培训来更好地理解心衰的分子和临床机制，从而推动NHLBI战略计划，旨在改善个人和公众的预防、诊断和治疗。利用梅奥诊所的主要举措，包括美国国立卫生研究院转化科学活动中心、卫生与人类服务部明尼苏达东南部灯塔项目、美国国立卫生研究院药物基因组学研究网络、美国国立卫生研究院心血管细胞治疗研究网络和明尼苏达州生物技术和医学基因组学合作伙伴关系，该项目在与地方/区域/国家卓越中心相互联系的发现-翻译-应用连续体中组建了协作和互补的导师团队。致力于NHLBI的规划重点，更新整合了多学科培训，以实现在不断发展的科学需求领域的能力。这项更新利用了学位授予项目；以社区为基础的心力衰竭登记和生物库；启用生物技术平台；并推出了诊断/治疗管道。与梅奥诊所个体化医学、再生医学和卫生保健提供科学的战略重点保持一致，课程内容丰富，包括个体化医学和药物基因组学课程；再生医学;系统生物学和生物信息学；分子成像;遗传流行病学;相对有效性;以及健康差异研究。一个研究员到教师的职业发展计划到位，以促进教师过渡，少数民族招聘和负责任的研究计划的实施，以确保持续的成功。更新强调了“心血管学”计划的愿景，在心血管研究的先锋提供最先进的培训。（摘要结束）

DESCRIPTION (provided by applicant): The "Cardiovasology" Post-doctoral Training Program at Mayo Clinic, in this renewal, requests continuation of support for years 36 to 40. Through four decades of mentored career development, the Program has realized the mission of preparing physicians and scientists for independent research careers in cardiovascular medicine and biology. Trainees have acquired rigorous scientific proficiency, excelled in productivity, established track- records in research support, and secured academic placements contributing to the nation's diverse workforce. Accomplishments have included strong recruitment and retention, interactive mentoring with outstanding NIH- funded faculty, robust infrastructure and cooperative environment ensuring launch of competitive careers. The renewal spans science-education-practice intersections to best equip next generation investigators. Mapped to draw from highest educational standards and cutting-edge technological platforms, the Program is customized to match the background and career path of each trainee, while widening interests and capabilities in pursuit of evolving scientific advances. Heart failure - with focus on translation from the bench to the bedside to populations - is the central theme, reflecting national morbidity and mortality trends. The Program actuates the NHLBI Strategic Plan by implementing training for the better understanding of molecular and clinical mechanisms of heart failure aimed at improved prevention, diagnosis, and treatment of individuals and the public-at-large. Leveraging major initiatives at Mayo Clinic, including the NIH Center for Translational Science Activities, Department of Health and Human Services Southeast Minnesota Beacon Program, NHLBI Heart Failure Clinical Research Network, NIH Pharmacogenomics Research Network, NHLBI Cardiovascular Cell Therapy Research Network, and Minnesota Partnership for Biotechnology and Medical Genomics, the Program assembles collaborative and complementary teams of mentors across the discovery-translation- application continuum interconnected with local/regional/national centers of excellence. Committed to NHLBI programmatic emphases, the renewal integrates multidisciplinary training to achieve competencies in evolving areas of scientific need. The renewal capitalizes on degree-granting programs; community-based heart failure registries and biobanks; enabling biotechnology platforms; and rolled-out diagnostics/therapeutics pipelines. Aligned with Mayo Clinic Strategic Priorities of Individualized Medicine, Regenerative Medicine, and Science of Health Care Delivery, offerings have been enriched to include curricula in personalized medicine and Pharmacogenomics; regenerative medicine; systems biology and bioinformatics; molecular imaging; genetic epidemiology; comparative effectiveness; and health disparities research. A fellow-to-faculty career development program is in place to foster faculty transition, and a minority recruitment and responsible conduct of research plans are implemented to ensure consistent success. The renewal underscores the vision of the "Cardiovasology" Program to provide most advanced training at the vanguard of cardiovascular research. (End of Abstract)