The Chemistry-Biology Interface Program at Johns Hopkins University

描述(由申请人提供)：本提案旨在重新支持约翰·霍普金斯大学化学-生物学接口(CBI)的培训计划，该计划成立于2005年，并于2008年得到美国国立卫生研究院的支持。目标是培养博士后学生使用化学和生物学工具进行生物医学研究。该计划是生物化学和分子生物学(彭博公共卫生学院)、药理学和分子科学(医学院)、生物物理和生物物理化学(医学院)、化学和生物分子工程(怀廷工程学院)的教职员工与他们在生物、生物物理和化学系(Zanvyl Krieger文理学院)的同事共同努力的成果。学生参与者在32个研究小组中有一系列不同的研究项目可供选择，包括合成、机理、酶学、分子成像和生物大分子结构。这些学生接受生物和化学科学的课程培训，包括一门专门为该项目设计的为期两学期的化学生物学课程，但向所有约翰·霍普金斯大学的学生开放。CBI计划的其他方面包括CBI论坛，在那里学生提出原始研究建议、研究更新、第一年研究轮换结果、为他们的论文辩护，以及年度务虚会。学生们沉浸在共同的课程中(独立于他们的研究顾问担任主要职务的部门)，直接申请CBI计划，并在完成学业后获得化学生物学博士学位。CBI计划于2005年秋季启动，资金来自该大学，该大学继续提供高水平的支持。国立卫生研究院目前为5名学生提供为期一年的支持。申请资助6名研究生。以咨询和指导的形式建立了广泛的支持网络，以最大限度地提高学生的成功。这使得该项目自2005年开始实施以来，留住了92%的学生。

DESCRIPTION (provided by applicant): This proposal seeks to renew support for a training program at the Chemistry-Biology Interface (CBI) at Johns Hopkins University that was established in 2005 and received NIH support in 2008. The goal is to train predoctoral students to carry out biomedical research using the tools of Chemistry and Biology. The Program is a collaborative effort between faculty in the Departments of Biochemistry and Molecular Biology (Bloomberg School of Public Health), Pharmacology and Molecular Sciences (School of Medicine), Biophysics and Biophysical Chemistry (School of Medicine), and Chemical and Biomolecular Engineering (Whiting School of Engineering), with their colleagues in the Biology, Biophysics, and Chemistry Departments (Zanvyl Krieger School of Arts & Sciences). Student participants have a diverse array of research projects including synthesis, mechanism, enzymology, molecular imaging, and biomacromolecular structure to choose from in 32 research groups. The students receive coursework training in the biological and chemical sciences, including a two-semester course in Chemical Biology designed especially for the Program, but open to all Johns Hopkins University students. Other aspects of the CBI Program include CBI Forum where students present original research proposals, research updates, first year research rotation results, and defend their theses, as well as an Annual Retreat. The students are immersed in a common curriculum (independent of the Department in which their research advisors hold primary appointments), apply directly to the CBI Program, and receive a Ph.D. in Chemical Biology upon completion. The CBI Program was initiated in fall 2005 using funding from the University, which continues to provide a high level of support. NIH currently provides one year of support for 5 students. Support is requested for 6 graduate students. An extensive network of support in the form of advising and mentoring is in place to maximize the students' success. This has resulted in >92% retention of students since the program began in 2005.