Imaging and Tissue Procurement Core

该核心的总体目标是提供执行和解释高级MR成像研究所需的高度技术专业知识;促进图像引导手术标本的收集;并将成像数据中的定量信息与组织生物学特性的分子标记物相关联。应该强调的是，实现这一目标所需的许多程序是非标准的，需要专业知识、尖端设备和复杂的实验或计算机分析，以便提取测试与每个科学项目相关的假设所需的信息。创建集成成像和组织分析的单个核心的决定反映了对获取图像引导样本的高度重视，这些样本可以提供从非侵入性代谢和生理成像数据中提取的临床成像变量与组织之间的直接联系肿瘤生物学的标记物。 成像和组织采购核心与UCSF TMEN脑癌中心的其他部分的相互作用如下图所示。与联合首席研究员Gabriele Bergers和Valerie M. Weaver、联合项目负责人Joanna J.菲利普斯和Soonmee Cha将主要负责规划、指导和执行TMEN U 54 UCSF脑癌中心的成像和组织采购活动。他们将由行政核心经理Annette Bistrup协助，并将利用中心的网页进行组织和成像请求/要求的查询和协议。 核心的主要目的是识别潜在的研究受试者，安排成像采集，识别潜在的活检部位，从手术室获取组织，去除组织样本的识别信息，分发新鲜肿瘤组织和配对的非肿瘤组织，以及正确处理和储存组织以备将来使用。该中心还将为UCSF TMEN脑癌中心提供神经放射学、神经病理学和形态学分析技术方面的专业知识。此外，该中心还将提供有关成像和病理学变量分析以及人体组织最佳使用和处理的培训和信息。TMEN脑癌中心成功的关键是获得原发性脑肿瘤组织和非肿瘤组织进行分析。成像和组织采购核心的组织结构如下图所示。将通过每周电话会议监测组织采购的进展。我们的目标是每2个月从3名患者中获得新鲜组织，5年内共增加90名患者。

The overarching goal of this Core is to provide the high degree of technical expertise required to perform and interpret advanced MR imaging studies; facilitate the collection of image guided surgical specimens; and relate the quantitative information derived from the imaging data to molecular markers of the biological properties of the tissue. It should be stressed that many of the procedures required to achieve this objective are nonstandard, requiring specialized knowledge, cutting-edge equipment, and sophisticated experimental or computer analysis in order to extract the information necessary for testing the hypotheses associated with each of the Scientific Projects. The decision to create a single Core that would integrate the imaging and tissue analysis reflects the high priority placed upon acquiring image-guided samples that can provide a direct link between the clinical imaging variables extracted from the noninvasive metabolic and physiologic imaging data and the tissue markers of tumor biology. The interaction of the Imaging and Tissue Procurement Core with the rest of the UCSF TMEN Brain Cancer Center is shown in the figure immediately below. Working closely with Co-Principal Investigators Gabriele Bergers and Valerie M. Weaver, Co-Project Leaders Joanna J. Phillips and Soonmee Cha will hold the primary responsibility for planning, directing, and executing the Imaging and Tissue Procurement activities ofthe TMEN U54 UCSF Brain Cancer Center. They will be assisted by the Administrative Core Manager Annette Bistrup and will exploit the Center's webpage for inquiries and protocols for tissue and imaging requests/requirements. The major purpose of the Core is to identify potential research subjects, schedule imaging acquisition, identify potential biopsy sites, procure tissue from the operating room, de-identify tissue samples, distribute fresh tumor tissue and paired non-tumor tissue, and properly handle and store tissue for future use. The Core will also provide expertise in neuroradiology, neuropathology, and morphologic analytical techniques to the UCSF TMEN Brain Cancer Center. In addition, the Core will provide training and information with respect to the analysis of imaging and pathology variables and the optimal use and handling of human tissue. Critical to the success of the TMEN Brain Cancer Center is access to primary brain tumor tissue and non-tumor tissue for analysis. The organizational structure for the Imaging and Tissue Procurement Core is depicted in the figure below. The progress of tissue procurement will be monitored through weekly teleconference meetings. Our goal is to obtain fresh tissue from 3 patients every 2 months for a total accrual of 90 patients over 5 years.