Determining the Functional Contribution of Prostate Tumor Microenvironment in Bon

项目摘要：在这个项目中，我们建议解决功能 低氧贡献 微环境（TME）对前列腺癌进展和转移性骨出现的影响 疾病本项目使用项目1中生成的小鼠模型，研究 缺氧、EMT和肌成纤维细胞代谢并在人类前列腺癌中验证这些发现 组织.这些研究将与Scadden实验室（项目3）合作进行， 确定可能与骨转移协同作用的骨细胞成分。我们也 建议详细评估癌细胞模仿间充质细胞能力的获得， 细胞类型，并进行上皮间质转化（EMT）计划，希望 收集信息以确定针对转移性前列腺的新治疗靶点 癌

Project Summary: In this project, we propose to address the functional contribution of hypoxic microenvironment (TME) to the progression of prostate cancer and emergence of metastatic bone disease. This project use the mouse models generated in the Project 1 to study the influence of hypoxia, EMT and myofibroblasts metabolism and validate these finding in human prostate cancer tissue. Such studies will be performed in collaboration Scadden Laboratory (Project 3), which will determine the cellular components of the bone that likely cooperate with bone metastasis. We also propose to evaluate in detail the acquisition of the ability of cancer cell to mimic mesenchymal cell types and undergo a program of epithelial to mesenchymal transition (EMT), in hopes of gathering information to identify new therapeutic targets against metastatic prostate cancer.