Center for Cancer Signaling Networks

我们III型过渡性眼镜蛇的主要目标是提供最先进的基因组和转基因核心 为布朗大学社区和东北部的附属中心提供服务，同时准备 在未来五年内过渡到独立支持。中心的科学主题是与 第二类Cobre支持是癌症信号网络。这一总的科学主题将继续下去，但 我们作为一个中心准备为更广泛的科学项目提供研究基础设施，而不是 最初在类型II Cobre中支持。与类型III相关的试点项目机制 COBRE将被用来促进专注于重大科学研究的教职员工团体的合作努力 可以立即转化为多PI和/或计划项目应用的问题。这项研究 最初提出的核心是老鼠转基因、成像、基因组学和生物信息学。前三名 它是从第一类科布雷延续下来的，而后者是作为新的核心设施而建立的。这个 生物信息学核心只得到了II型科布雷的短暂支持，因为它演变成了一个独立的中心 (计算分子生物学中心)。成像核心也毕业于Cobre Support 现在作为一个独立的设施运作。成像核心呈指数增长，是一个主要的 为布朗和该州的调查人员提供的资源。我们有使用Cobre资源来 开发可靠的研究核心，其科学重点使他们能够实现独立 机制。我们正在请求支持的其余两个核心正在迅速变得更多 被罗德岛的科学界严重依赖。我们将继续改进这些核心 到可以由用户费用、个人和 计划类型的助学金支持，需要时大学费用分担。

The major goal of our type III transitional COBRE is to provide state of the art genomic and transgenic core services to the Brown University community and affiliated centers in the Northeast while preparing to transition to independent suport in the next five years. The scientific theme of the Center developed with type II COBRE support was cancer signaling networks. This general scientific theme will be continued but we as a center are poised to provide the research infrastructure for a wider range of scientific projects than were supported initially in the type II COBRE. The pilot project mechanism associated with the type III COBRE will be used to nucleate collaborative efforts by groups of faculty focusing on significant scientific problems that can immediately translate into multi-PI and/or program project applications. The research cores originally proposed were Mouse Transgenics, Imaging, Genomics and Bioinformatics. The first three carried over from the type I COBRE while the latter was established as a new core facility. The Bioinformatics core was only briefly supported by the type II COBRE as it evolved into an independent center (Center for Computational Molecular Biology). The Imaging core was also graduated from COBRE support and now functions as an independent facility. The imaging core has grown exponentially and is a major resource for investigators at Brown and in the state. We have a track record of using COBRE resources to develop solid research cores whose scientific focus allows them to achieve independence from this mechanism. Our remaining two cores for which we are requesting support are quickly becoming more heavily relied on by the scientific community here in Rhode Island. We will continue to improve these cores to the point where they can be independently supported by a combination of user fees, individual and program-type grant support, and University cost-sharing when needed.