Molecular Pathogenesis of Infectious Diseases

描述（由申请人提供）：本申请是我们的跨学科博士前培训补助金的传染病的分子发病机制在科罗拉多医学院的第二次竞争更新。这一新兴的研究领域包括微生物毒力决定因子的分子生物学和生物化学研究、宿主抗性机制、感染过程中转录和翻译的调节、在感染中起关键作用的微生物和宿主细胞分子的结构-功能分析、 分析细菌和病毒与体外分化的宿主细胞的相互作用，以及使用野生型或转基因微生物菌株和宿主动物在动物模型中研究细菌和病毒感染。我们的培训教师的高度互动的成员已经证明了在这些领域的创新研究的生产力，已经从美国国立卫生研究院，国家科学基金会，国防部和其他授予机构获得了研究资金，并积累了多年的经验，在培训博士前的学生在所需的多学科方法对传染病的发病机制的前沿研究。除了执行他们的指导研究项目，我们的学员将参加教学课程，研讨会，期刊俱乐部和研究进展会议，将培训他们识别重要的新的研究问题，设计良好的控制实验使用各种各样的分子，细胞和体内技术，批判性地评估和展示他们的结果，理解并将道德原则应用于他们的研究。学生被选中任命为这个培训计划后，他们已经完成了他们所需的课程工作，通过了他们的初步和综合考试，并开始他们的论文研究。我们的综合，跨部门的培训补助金的广度将准备学生在学术界和生物技术的成功职业生涯。这一充满活力的培训补助金非常成功。它促进了培训资助教师之间新的研究合作和赠款，改进了课程，并促进了博士前学员和培训师之间的跨学科互动。在五年以来，我们的传染病的分子发病机制的培训计划于2007年更新，我们的培训教师从21增加到24，超过30名博士前学员在任何给定的时间填充了培训补助金教师的实验室在过去的8年。此外，我们的学员撰写的出版物数量从2002-2006年期间的29份增加到2007年以来的62份。我们要求在未来五年每年四个职位，以保持我们的学生在我们的培训补助金实验室调查的传染病分子发病机制的多个方面接受的优秀跨学科培训的水平 教师。

DESCRIPTION (provided by applicant): This application is for the second competing renewal of our interdisciplinary pre-doctoral training grant on The Molecular Pathogenesis of Infectious Diseases at the University of Colorado School of Medicine. This emerging area of investigation encompasses molecular biological and biochemical studies on microbial virulence determinants, host resistance mechanisms, regulation of transcription and translation during infection, structure-function analysis of microbial and host cell molecules that play key roles in infections, analysis of interactions of bacteria and viruses with differentiated host cells in vitro, and studis on bacterial and viral infections in animal models using either wild-type or genetically modified strains of microbes and host animals. The highly interactive members of our training faculty have proven productivity for innovative research in these areas, have secured research funding from NIH, NSF, DOD and other granting agencies, and accumulate years of experience in training pre-doctoral students in the multidisciplinary approaches needed for cutting-edge research on the pathogenesis of infectious diseases. In addition to performing their mentored research projects, our trainees will participate in a comprehensive program of didactic courses, seminars, journal clubs, and research-in-progress meetings that will train them to identify important new research questions, design well-controlled experiments using a wide variety of molecular, cellular and in vivo techniques, critically evaluate and present their results, and understand and apply principles of ethics to their research. Students are selected for appointment to this training program only after they have completed their required course work, passed their preliminary and comprehensive examinations and begun their dissertation research. The breadth of our integrated, interdepartmental training grant will prepare students for successful careers in academia and biotechnology. This dynamic training grant has been remarkably successful. It has fostered new research collaborations and grants among the training grant faculty, improved the curriculum, and fostered interdisciplinary interactions among the pre-doctoral trainees and trainers. In the five years since our training program on the Molecular Pathogenesis of Infectious Diseases was renewed in 2007, our training faculty increased from 21 to 24, and over 30 pre-doctoral trainees have populated at any given time the labs of training grant faculty for the past 8 years. In addition, the number of publications authored by our trainees grew from 29 in the 2002-2006 year period to 62 since 2007. We request four positions each year for the next five years to maintain the level of outstanding interdisciplinary training that our students receive in the multiple aspects of molecular pathogenesis of infectious diseases that are investigated in the laboratories of our training grant faculty.