Associate Professor of Neurology and Psychiatry

项目随附资料（见说明）： 项目资助的临床核心将对参与项目资助（PPG）的所有受试者进行认知和临床评估。临床核心将招募和评估轻度认知障碍（MCI）受试者，并将继续随访现有的正常健康对照受试者。核心人员将审查潜在受试者的研究方案，并获得完全知情同意，进行方案所需的认知、临床和神经系统评估。随访预约和与受试者的持续电话联系将通过核心协调。临床核心将与ADRC和老化研究协调，以确保准确及时地将临床信息、认知评分和与PPG数据集相关的其他数据传输至成像、方法学和统计学（IMS）核心，以进行数据分析并与PIB PET和成像数据进行关联。PPG协调委员会由临床核心、管理核心、IMS核心的PI以及3个项目的PI和Co-I组成，PPG管理员将监督临床核心。核心小组的所有调查人员以及为实现本核心小组的目标而与他们互动的所有个人多年来一直在一起工作，这进一步保证了拟议的工作将得到适当的执行。

PROJECT SUIVIMARY (See instructions): The Clinical Core of the Program Project Grant will perform the cognitive and clinical assessments for all subjects taking part in the Program Project Grant (PPG). The Clinical Core will recruit and assess subjects with Mild Cognitive Impairment (MCI) and will continue to follow existing Normal Healthy Control Subjects. The Core will review the study protocols with potential subjects and obtain full informed consent, perform cognitive, clinical and neurological assessments necessary for the protocol. Follow-up appointments and ongoing telephone contact with subjects will be coordinated through the Core. The Clinical Core will coordinate with the ADRC and the Aging Study to ensure accurate and timely transfer of clinical information, cognitive scores and other data relevant to the PPG dataset and subsequently to the Imaging, Methodology and Statistics (IMS) Core for data analysis and correlation with PIB PET and imaging data. The PPG Coordinating Committee comprising the Pis of the Clinical Core, Administrative Core, IMS Core, and Pis and Co-Is of the 3 projects and the PPG Administrator will oversee the Clinical Core. All of the Investigators in the Core and all of the individuals with whom they interact to achieve the aims of this Core have worked together for many years, adding to the assurance that the proposed work will be carried out appropriately.