High School Student NeuroResearch Program (HSNRP)

描述（申请人提供）：亚利桑那大学（UA）高中生神经研究计划（HSNRP）将引进，培训和培养越来越多的多样化人才亚利桑那州高中生，包括在正常和异常神经系统，神经系统疾病，以及鼓励追求先进的研究经验和健康/科学相关的职业。我们将利用强大的基础设施，有效的招聘策略，高水平的学生/教师导师参与，团队精神，以及我们长期以来联邦资助的多学科/多专业弱势高中生和医科学生暑期研究计划的优秀学员生产力，为这个新的专业神经研究（NR）计划开发培训模式。未来5年，每年将有12至14名全日制暑期高中学员获得神经研究（NR）经验的密切指导; 2-4名将被重新任命为高级NR的本科生。这些将被整合到一个创新的调查为基础的医学无知暑期研究所（SIMI）交织生物医学已知和未知（“我们知道我们不知道，不知道我们不知道，并认为我们知道但不知道”）与特色NR主题，并通过定期的丰富活动全年持续。SIMI强调“翻译翻译”，包括高中水平的简要介绍病理学，专题研讨会，实验室/领导/多媒体技能研讨会，临床相关性，社交网络和职业咨询。一个独特的虚拟临床研究中心/医疗中心形成了培训和国家/国际网络的中心。在基础和临床部门以及专业卓越中心内，并由充满活力的HSNRP领导团队和咨询委员会监督，高中学生研究将包括跨学科主题和体内，体外，原位，计算机模拟和神经生物学/疾病建模方法，包括帕金森，阿尔茨海默病，尼曼-皮克C疾病，ALS，癫痫，艾滋病毒脑病，头部创伤，脑积水，肌肉萎缩症，疼痛/成瘾药理学、分子精神病学、认知、脑发育、衰老、智力迟钝、血脑屏障/神经保护、神经成像、神经基因组学/蛋白质组学、神经工程、脑深部刺激、脑癌、脑血管疾病、中风和康复。基于我们~25年的跟踪记录，并建立了获得大量不同的弱势亚利桑那州学生的渠道，这些学生反映在474名接受SIMI培训的高中生中，迄今为止，许多学生从事基础/临床神经研究，我们期望HSNRP：培养一个不断扩大的多元化研究人员、医生和其他卫生专业人员网络;为神经研究管道和企业做出贡献;并通过社区参与提高“神经健康”素养。正在进行的短期和长期评价，包括调查、数据库登记和职业组合，将记录培训模式的效力并促进联网。

DESCRIPTION (provided by applicant): The University of Arizona (UA) High School Student NeuroResearch Program (HSNRP) will introduce, train, and nurture a growing cadre of diverse talented Arizona high school students including under-represented minorities in basic, translational, and clinical research on the normal and abnormal nervous system, neurological disorders, and stroke as well as encourage pursuit of advanced research experiences and health/ science-related careers. We will leverage the strong infrastructure, effective recruitment strategies, high level of student/faculty mentor participation, esprit-de-corps, and outstanding trainee productivity of our long-standing federally funded multidisciplinary/multispecialty disadvantaged high school student and medical student summer research programs to develop the training model for this new specialized NeuroResearch (NR) program. Twelve to 14 full-time summer high school trainees annually for the next 5 years will be offered an expanding menu of closely mentored NeuroResearch(NR) experiences; 2-4 will be reappointed as under- graduates for advanced NR. These will be integrated into an innovative inquiry-based Summer Institute on Medical Ignorance (SIMI) interweaving biomedical Knowns and Unknowns ("what we know we don't know, don't know we don't know, and think we know but don't") with featured NR topics and sustained by periodic enrichment activities year round. SIMI emphasizes "translating translation" and includes a high school level brief Introduction to Pathobiology, topical seminars, laboratory/leadership/multimedia skill workshops, clinical correlations, social networking, and career advising. A unique Virtual Clinical Research Center/Questionarium forms a centerpiece for training and national/international networking. Within basic and clinical departments and specialized Centers of Excellence and overseen by an energetic HSNRP Leadership Team and Advisory Committee, high school student research will encompass cross-cutting themes and in vivo, in vitro, in situ, in silico, and modeling approaches to neurobiology/disorders including Parkinson, Alzheimer, Niemann-Pick C diseases, ALS, epilepsy, HIV encephalopathy, head trauma, hydrocephalus, muscular dystrophy, pain/ addiction pharmacology, molecular psychiatry, cognition, brain development, senescence, mental retardation, blood-brain barrier/neuroprotection, neuroimaging, neuro-genomics/proteomics, neuroengineering, deep brain stimulation, brain cancer, cerebrovascular disease, stroke, and rehabilitation. Based on our ~25-year track record and established access to large diverse pools of disadvantaged Arizona students reflected in 474 SIMI- trained high school students followed to date with many in basic/clinical NeuroResearch, we expect HSNRP to: cultivate an expanding network of diverse researchers, physicians and other health professionals; contribute to the NeuroResearch pipeline and enterprise; and improve "neurohealth" literacy through community engagement. Ongoing short-term and long-term evaluation including surveys, database registry and career portfolios will document efficacy of the training model and promote networking.