Center for Integrative Neuroscience

描述（由申请人提供）：本提案旨在在内华达大学里诺分校（UNR）建立一个综合神经科学卓越生物医学研究中心（COBRE）。神经科学的研究正在许多方面进行，并解决基础科学和临床科学的基本问题。这个COBRE的目的是建立一个研究中心，通过连接和交叉促进UNR的几个研究单位，促进跨学科的互动和神经功能，损伤和修复的研究，这些研究单位已经在神经科学方面建立了专注的专业团队，从分子到行为，从理解正常结构和功能到神经缺陷及其治疗。该中心将涵盖3个不同的学院和医学院，并将支持来自心理、生物、生物医学工程、生理和细胞生物学等系的5名成绩优异的初级教师领导的项目。这些教师的研究和专业发展将由一支强大的成功研究人员团队指导，他们也将带来来自多个学科的观点和专业知识。该中心还将通过建立两个新的核心设施，为整个机构提供支持项目的基础设施和新的研究机会。一个核心将支持结构和功能磁共振成像（MRl）的培训、使用和分析。这个核心将第一次为UNR提供由MRl提供的标准研究工具。第二个核心将通过开发一个数据库来支持针对不同患者群体的研究，该数据库将允许研究人员识别和招募具有明确定义的神经病变的参与者。该中心和新的核心设施将在全新的方向上扩展UNR的研究优势和转化神经科学，同时提供在基础和临床研究中具有广泛应用的基础设施，从而支持校园和州内许多学科和项目的使用和研究协同作用。

DESCRIPTION (provided by applicant): This proposal is to create a Center of Biomedical Research Excellence (COBRE) in Integrative Neuroscience at the University of Nevada, Reno (UNR). Research in the neurosciences is proceeding on many fronts and addressing fundamental questions in both basic and clinical science. The aim of this COBRE is to establish a research center that can promote interdisciplinary interactions and investigations of neural function, impairments, and repair, by bridging and cross-fertilizing several research units at UNR that have already developed teams of focused expertise in neuroscience, from molecular to behavioral and from understanding normal structure and function to neurological deficits and their treatment. The center will span 3 different colleges and the Medical School, and will support projects led by 5 highly accomplished junior faculty drawn from the departments of Psychology, Biology, Biomedical Engineering, and Physiology and Cell Biology. The research and professional development of these faculty will be mentored by a strong team of successful researchers who will also bring perspectives and expertise drawn from many disciplines. The center will also provide the infrastructure to support the projects as well as new research opportunities throughout the institution by establishing two new core facilities. One core will support training, use, and analysis of structural and functional magnetic resonance imaging (MRl). This core will provide - for the first time - access at UNR to the now standard research tools provided by MRl. The second core will support investigations directed at different patient populations by developing a database that will allow researchers to identify and recruit participants with well defined neurological lesions. Both the center and new core facilities will expand research strengths and translational neuroscience at UNR in entirely new directions, while providing infrastructure that has broad applications in both basic and clinical research and can thus support use and research synergisms across many disciplines and programs on campus and in the state.