Increasing AIAN Research Engagement through a Culturally Adapted Ethics Training

描述(由申请人提供)：美国印第安人和阿拉斯加原住民(AIAN)面临着明显的健康差距，AIAN特有的研究在解决AIAN健康问题方面落后于其他种族和民族数据。让AIAN社区成员参与研究过程可以减少研究的不信任，增加科学的严谨性，并使更多的AIAN作为参与者和潜在的未来学者接触到研究。然而，社区参与研究(Cenr)的一个重要障碍是缺乏针对社区合作伙伴的具有文化相关性的人类受试者的研究伦理教育。这项由研究人员发起的早期提案(PA-13-302)针对的是AIAN迫切需要更多地参与设计、实施和传播联邦资助的研究，这些研究在印度农村进行，并影响其社区的健康和福利。通过这样做，这项研究满足了美国国立卫生研究院(NIH)的一个主要目标，即加强我们国家的研究能力，扩大我们的研究基础，并激发当代和未来几代研究人员对科学的热情。总体目标是通过为合作IRB培训计划(CITI)创建一个与文化相关的培训模块来加强AIAN的研究能力，并增加AIAN社区对NIH资助的研究的参与，该培训模块对AIAN来说是适用的、可获得的和可通过的，同时提高了其教育价值。“研究中的学生”模块之所以被选为改编单元，是因为它全面涵盖了人类主体的全方位保护和语言水平。使用cenr方法，这项创新的研究将通过创建文化上适当的培训，将贝尔蒙特原则应用于基本的人类受试者保护，增加AIAN社区对研究的知情参与。目标1旨在确定当前CITI“在校学生”培训模块中需要AIAN社区研究人员适应文化的语言和研究范例。目标1将通过一个迭代过程实现，该过程利用AIAN社区领袖、研究人员和具有AIAN研究专长的伦理学家组成的国家专家小组的专门知识。AIM 2旨在开发并通过心理测量学验证该模块的文化适应性和AIAIN人群可访问性版本，旨在通过增加研究伦理知识、研究效率和研究信任来增加AIAN社区成员对研究的参与。目标2将通过初步贝塔测试和随后在具有全国代表性的AIAN潜在研究伙伴样本中进行的大规模双臂随机对照试验来实现。该项目的目标3是将调查结果转化为政策和实践指南。AI 3将通过花旗、美国印第安人全国大会和美国印第安人高等教育联盟传播立即使用的培训来实现。这项建议的意义在于有可能在印度全国范围内推动NIH资助的研究在伦理方面的科学培训。它旨在发展为生活在美国各地的AIAN服务的研究能力，AIAN是一个面临健康差距扩大风险的群体。

DESCRIPTION (provided by applicant): American Indian and Alaska Natives (AIAN) face glaring health disparities, and AIAN-specific research lags behind other racial and ethnic data in addressing AIAN health concerns. Engaging AIAN community members in the research process can reduce research mistrust, increase scientific rigor, and expose more AIAN to research both as participants and potentially as future scholars. A significant barrier to community engaged research (CEnR), however, is the absence of culturally relevant human subject's research ethics education for community partners. This early stage investigator initiated (PA-13-302) proposal addresses the urgent need to increase participation of AIAN in the design, implementation and dissemination of federally funded research conducted in Indian Country and affecting the health and welfare of their communities. By doing so, this study addresses a primary goal of the National Institutes of Health (NIH) "to strengthen our nation's research capacity, broaden our research base, and inspire a passion for science in current and future generations of researchers." The overarching goal is to strengthen research capacity and increase AIAN community involvement in NIH-funded research by creating a culturally relevant training module for the Collaborative IRB Training Initiative (CITI) that is applicable, accessible and passable for AIAN while enhancing its educational value. The "student in research" module was selected for adaptation because of its comprehensive coverage of a full range of human subject's protections and language level. Using a CEnR approach, this innovative study will increase informed AIAN community involvement in research by creating culturally appropriate training that applies Belmont principles to fundamental human subjects protections. Aim 1 seeks to identify language, and research examples in the current CITI "student in research" training module that requires cultural adaptation for AIAN community researchers. Aim 1 will be achieved through an iterative process that draws on the expertise from a national expert panel of AIAN community leaders, researchers and ethicists with expertise in AIAN research. Aim 2 seeks to develop and psychometrically validate a culturally adapted and AIAIN population accessible version of the module designed to increase AIAN community members' involvement in research through increased research ethics knowledge, research efficacy, and research trust. Aim 2 will be achieved through preliminary beta testing and a subsequent large-scale two-arm randomized controlled trial among a nationally representative sample of AIAN potential research partners. Aim 3 of the project is to translate the findings into policy and practice guidelines. Ai 3 will be achieved by disseminating the training for immediate use through the CITI, National Congress of American Indians, and American Indian Higher Education Consortium. The significance of this proposal lies in the potential to advance science in ethics training for NIH-funded research across Indian Country. It is geared toward developing research capacity serving AIAN living across the U.S., a group at risk for expanding health disparities.