Scientific Core: Acquisition, Synthesis, and Characterization of Nanomaterials

科学核心负责将在中心研究的所有粒子。这些职责包括对所有颗粒进行彻底的化学和物理表征，合成新的颗粒以完成文库并引入新的功能，如荧光，以及设计和合成高度专业化的颗粒，这些颗粒将用于测试来自体外和体内生物学研究的关于纳米生物界面有害作用的假设。工程纳米材料（ENM）库（表1）的准确，全面和可解释的表征是肺毒性研究的绝对必要条件。必须描述其物理和化学性质，以便为解释分子和细胞损伤机制提供基础。制造商关于 他们提供的材料提供不同程度的完整性和准确性。科学核心将进行所有自己的测量（见第IB节），并以统一和可解释的格式向项目负责人提供可靠的数据。

The scientific core is responsible for all of the particles that will be studied in the center. These responsibilities include thorough chemical and physical characterization of all particles, synthesizing new particles for the purposes of completing libraries and for introducing new functionality such as fluorescence, and designing and synthesizing highly specialized particles that will be used to test hypotheses arising from the in vitro and in vivo biological studies about injurious effects at the nano-bio interface. Accurate, thorough and interpretable characterization of Engineered Nanomaterial (ENM) libraries (Table 1) is an absolute necessity for studies of pulmonary toxicity. The physical and chemical properties must be delineated in order to provide a basis for interpreting molecular and cellular injury mechanisms. Manufacturers' statements about the properties of the materials that they ship provide varying degrees of completeness and accuracy. The Scientific Core will carry out all of its own measurements (see section IB) and provide reliable data in a uniform arid interpretable fonnat to the project leaders.