Implementation of an Elementary and Robust Implantable Sensor for Musculoskeletal

描述(申请人提供)：智能植入物在肌肉骨骼疾病中促进个性化药物的临床应用是巨大的。在患者特定的基础上，植入物的物理环境提供了关于愈合进程和预后的丰富的诊断数据。通过个性化药物的个性化护理，通过促进为个别患者提供更好的诊断和最佳治疗方案，降低了成本并改善了结果。以前用于研究的智能种植系统由于复杂性、成本和所需的修改而不能适应日常临床实践 寄主植入。在这个项目中，我们将开发和实现一种简单、坚固、廉价、无电池、无遥测、单组件、无电气连接的植入式传感器，用于肌肉骨骼智能植入物。我们将证明该传感器符合在日常临床实践中促进个性化肌肉骨骼医学的标准。这些传感器将被集成到脊柱植入物中，以(A)客观地将活体内力与脊柱融合的进展相关联，以及(B)实时量化在山羊颈椎动态活动期间体内多轴向椎间力(轴向和剪力)。

DESCRIPTION (provided by applicant): The clinical utility of smart implants to facilitate personalized medicine in musculoskeletal disease is vast. On a patient-specific basis, the implant's physical environment provides a wealth of diagnostic data regarding the progression of healing and prognosis of an outcome. Customized care through personalized medicine reduces costs and improves outcomes by facilitating better diagnoses and optimal treatment regimens for individual patients. Previous smart implant systems used for research have not been adaptable to daily clinical practice due to complexity, cost, and the required modification of host implants. In this project, we will develop and implement a simple, robust, inexpensive, battery-less, telemetry-less, single component implantable sensor with no electrical connections for musculoskeletal smart implants. We will demonstrate that the sensor meets the criteria to facilitate personalized musculoskeletal medicine in daily clinical practice. The sensors will be integrated into spinal implants to (a) objectively correlate in vivo force to progress of spinal fusion, and (b) quantify real time in vivo multi-axial interbody force (axial and shear) during dynamic activities in the goat cervical spine.