Brain plasticity and rehabilitation after stroke

描述(由申请人提供)：这是一个令人兴奋的时间成为一名研究人员在大脑可塑性领域。多年来旨在改善患者结局的研究已经到了为人类受试者转化为新疗法的地步。在接下来的几年里，临床科学家将非常需要继续这项工作。目前的提案侧重于这一需求，同时 研究中风康复中的关键问题。这项拨款的主要科学重点是中风后大脑的可塑性及其与康复的关系。无数的研究已经表征了中风后大脑结构和功能的变化及其与改善患者预后的关系。这一科学领域受益于测量人类患者大脑可塑性的技术，以及评估有前景的恢复性疗法的临床试验。在这笔赠款的支持下，参加培训的PMR住院医师、参加DPT计划的物理治疗师和临床研究员将各自参与一些研究项目。目前正在进行的项目包括研究机器人以改善中风后的运动功能，以及研究遗传变异对中风结果的影响。本文提出的新研究包括评估多巴胺能药物以改善患者预后，在康复病房使用密集阵列脑电实施床边脑电地形图，以及研究远程康复系统以减少中风后的残疾。除了为PI提供更多时间进行以患者为中心的研究并增加作为导师的可用性外，K24赠款还将支持一名计算机科学家和一名生物统计学家，这两人都为新的以患者为中心的研究人员提供关键技能。加州大学欧文分校拥有广泛的临床研究人员培训资源。其中最主要的是临床转化研究所，由NIH CTSA赠款支持，该研究所提供了许多与当前提案的使命相关的服务，包括科学核心、生物信息学支持和护理支持。这位候选人长期以来一直致力于在以患者为导向的研究中指导临床科学家，并期待着在未来增加这一活动。

DESCRIPTION (provided by applicant): It is an exciting time to be an investigator in the area of brain plasticity. Years of research aimed at improving patient outcomes is reaching the point of translation into new therapies for human subjects. In the coming years there will be a great need for clinical scientists to continue this work. The current proposal focuses on this need while examining key questions in stroke rehabilitation. The main scientific focus of this grant is brain plasticity after stroke and its relationship to rehabilitation. Countless studies have characterize changes in brain structure and function after stroke and their relationship to improved patient outcomes. This area of science benefits from techniques to measure to brain plasticity in human patients, and from clinical trials to evaluate promising restorative therapies. Under the aegis of this grant, PMR residents in training, physical therapists in DPT programs, and clinical fellows will each take part in a number of research projects. Currently ongoing projects include the study of robotics to improve motor function after stroke, and the study of genetic variation influences on stroke outcomes. New research proposed herein includes evaluation of dopaminergic drugs to improve patient outcomes, implementation of bedside brain mapping in the rehabilitation ward using dense array EEG, and a study of a telerehabilitation system to reduce disability after stroke. In addition to providing more time for the PI to perform patient-oriented research and to have increased availability as a mentor, the K24 grant will also support a computer scientist and a biostatistician, both of whom provide critical skills to new investigators in patient-oriented research. The University of California, Irvine has wide-ranging resources for training of clinical investigators. Chief among these is the Institute for Clinical Translational Research, supported by an NIH CTSA grant, which has numerous offerings relevant to the mission of the current proposal, including scientific cores, bioinformatics support and nursing support. The candidate has long been committed to mentoring clinical scientists in patient-oriented research and looks forward to increasing this activity in the future.