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Interactions between IL-15 and TGF-beta signalling pathways reveal novel therapeutic strategies to boost anti-cancer immunity

Interactions between IL-15 and TGF-beta signalling pathways reveal novel therapeutic strategies to boost anti-cancer immunity
IL-15 和 TGF-β 信号通路之间的相互作用揭示了增强抗癌免疫的新治疗策略
批准号:
nhmrc : 1140406
负责人:
金额:
$30.05万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
翻译
该项目将确定是否可以将新的免疫抑制检查点与BRAFV600E抑制协同作用,以重新激活并允许NK细胞最大限度地发挥其抗肿瘤免疫功能,防止癌症扩散。这是一种全新的方法,将允许在手术和局部放疗和/或化疗后针对NK细胞的黑色素瘤治疗方案的更合理设计。
英文摘要
This project will determine if new immune inhibitory checkpoints can be synergistically targeted with BRAFV600E inhibition to reactivate and allow NK cells to maximise their anti-tumour immune functions and prevent cancer spread. It is a completely novel approach that will allow for the more rational design of melanoma treatments that targets NK cells following surgery and local radiotherapy and/or chemotherapy.
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