Bone Microenvironment Contributions to Metastatic Disease
Bone Microenvironment Contributions to Metastatic Disease
批准号:
8933402
负责人:
David T Scadden
金额:
$45.0万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-26 至 2016-07-31
关键词:
AddressAnimalsBone neoplasmsCell CommunicationCellsCollaborationsDiseaseElementsEngraftmentFlow CytometryFosteringGenotypeHistocompatibility TestingHumanImageLabelLifeLocalized DiseaseMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of prostateMeasurementMesenchymalMesenchymal Cell NeoplasmMetastatic LesionMetastatic Neoplasm to the BoneMetastatic toMolecularNeoplasm MetastasisPlayPopulationProcessRegulationRoleSiteSupporting CellTechnologyTestingTimeTissuesTransgenic AnimalsWorkbasebonebone cellcancer cellcancer typecell typein vivointerestneoplastic cellprostate cancer celltooltumor
中文摘要
项目摘要:转移是一个多步骤的过程,涉及多种不同的组织成分
支持异位癌细胞。我们认为,间充质细胞与癌细胞的相互作用发挥了重要作用。
在转移部位的癌症成功植入中起关键作用。我们将检验这个假设
通过检查和操纵与原发性骨髓瘤相互作用的间充质细胞的特定亚群,
确定基因型的前列腺癌细胞。
PHS
英文摘要
Project Summary: Metastasis is a multi-step process that involves multiple different tissue components
supporting a heterotopic cancer cell. We propose that mesenchymal cell interactions with cancer cells play a
critical role in the successful engraftment of the cancer in a metastatic site. We will test that hypothesis
through the examination and manipulafion of specific subsets of mesenchymal cells interacting with primary
prostate cancer cells of defined genotype.
PHS
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Functional consequences of stem and progenitor cell heterogeneity
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批准号:10413502
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项目类别:
-
资助金额:$5.04万
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财政年份:2020
-
负责人:David T Scadden
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依托单位:
Enhancing regeneration of stem cell-derived HIV-specific immune effectors
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批准号:10409803
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项目类别:
-
资助金额:$55.27万
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财政年份:2020
-
负责人:David T Scadden
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依托单位:
Enhancing regeneration of stem cell-derived HIV-specific immune effectors
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批准号:10163909
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项目类别:
-
资助金额:$49.97万
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财政年份:2020
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负责人:David T Scadden
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依托单位:
Functional consequences of stem and progenitor cell heterogeneity
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批准号:10188996
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项目类别:
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资助金额:$5.04万
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财政年份:2020
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负责人:David T Scadden
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依托单位:
Clonal tracking and molecular characterization of hematopoiesis under stress
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批准号:10413504
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项目类别:
-
资助金额:$5.04万
-
财政年份:2020
-
负责人:David T Scadden
-
依托单位:
Enhancing regeneration of stem cell-derived HIV-specific immune effectors
-
批准号:10601073
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项目类别:
-
资助金额:$58.87万
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财政年份:2020
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负责人:David T Scadden
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依托单位:
Project 1: Implications of blood cell heterogeneity for CV disease
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批准号:10238040
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项目类别:
-
资助金额:$39.28万
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财政年份:2019
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负责人:David T Scadden
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依托单位:
Project 1: Implications of blood cell heterogeneity for CV disease
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批准号:10469350
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项目类别:
-
资助金额:$39.28万
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财政年份:2019
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负责人:David T Scadden
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依托单位:
Project 1: Implications of blood cell heterogeneity for CV disease
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批准号:10670732
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项目类别:
-
资助金额:$39.28万
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财政年份:2019
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负责人:David T Scadden
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依托单位:
Functional consequences of stem and progenitor cell heterogeneity
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批准号:10641537
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项目类别:
-
资助金额:$261.17万
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财政年份:2017
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负责人:David T Scadden
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依托单位:
Administrative Core
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批准号:10641538
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项目类别:
-
资助金额:$2.58万
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财政年份:2017
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负责人:David T Scadden
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依托单位:
Project 2 - Cell of origin contributions and vulnerabilities in clonal hematopoiesis
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批准号:10641541
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项目类别:
-
资助金额:$50.99万
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财政年份:2017
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负责人:David T Scadden
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依托单位:
In vivo tracking of the hematopoietic stem cell clonal dynamics using a novel multi-fluorescent transgenic mouse model
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批准号:9134179
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项目类别:
-
资助金额:$23.95万
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财政年份:2015
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负责人:David T Scadden
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依托单位:
Cell and Molecular Dynamics of Hematopoiesis In Vivo
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批准号:9527128
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项目类别:
-
资助金额:$73.96万
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财政年份:2015
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负责人:David T Scadden
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依托单位:
CORE A: Administrative and Biostatisitcs Core
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批准号:8897536
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项目类别:
-
资助金额:$14.37万
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财政年份:2015
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负责人:David T Scadden
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依托单位:
In vivo tracking of the hematopoietic stem cell clonal dynamics using a novel multi-fluorescent transgenic mouse model
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批准号:8969345
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项目类别:
-
资助金额:$19.97万
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财政年份:2015
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负责人:David T Scadden
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依托单位:
Project 1: Clonal Dynamics Guiding Curative Therapies for Acute Myeloid Leukemia
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批准号:8866712
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项目类别:
-
资助金额:$51.05万
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财政年份:2015
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负责人:David T Scadden
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依托单位:
Cell and Molecular Dynamics of Hematopoiesis In Vivo
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批准号:9312803
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项目类别:
-
资助金额:$76.19万
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财政年份:2015
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负责人:David T Scadden
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依托单位:
A defend and destroy approach to curing HIV
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批准号:9254596
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项目类别:
-
资助金额:$228.57万
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财政年份:2015
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负责人:David T Scadden
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依托单位:
Mechanisms of Hematopoiesis in AIDS
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批准号:8528891
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项目类别:
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资助金额:$29.64万
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财政年份:2012
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负责人:David T Scadden
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依托单位:
海外基金