Healthy and At-Risk Populations

健康和高危人群计划（HARP）共有34名核心成员，代表4所学校和13个部门。在本资助年度，该计划的癌症相关资金总额为2080万美元。其中，同行评审的资金总额为1350万美元，包括来自国家癌症研究所的340万美元。与其他项目一样，JCCC促进了一些互动活动和共享资源，以支持HARP的研究人员。在当前的赠款周期内，JCCC以CCSG发展基金、机构支持和慈善捐赠的形式向HARP提供的资金共计2043085美元。这些资金支持种子赠款，计划领域的领导支持，以及由HARP在社区主办的年度差异研讨会。HARP项目是高度互动的，其15%的出版物反映了项目内的努力，11%报告了项目间的合作。178篇（28%）发表在高影响力期刊上。预防试验累计1,186例，筛查1,021例，早期发现/诊断1,151例，流行病学/obs/结局1,426例，相关性113例。HARP的目标是促进对癌症风险和保护因素的理解，并确定战略，使最新的癌症预防知识和技术能够为广大人口所用。HARP的研究涵盖四个广泛的重点领域：1。癌症风险和保护因素/病因学，2.预防为主，3。筛查/早期检测，4.支持社区参与的基础设施项目。该计划的研究有两个主要主题：癌症差异和转化研究（主要是T3和T4）。这些主题并不相互排斥，事实上，该计划中的大多数项目都包含这两个主题。我们的癌症差异研究重点是癌症预防和控制干预措施，以减轻洛杉矶及其他地区低收入，少数民族和其他社会和医疗服务不足的人群的差异，并使加州大学洛杉矶分校成为全国首屈一指的癌症差异研究计划之一。

The Healthy and At-Risk Populations program (HARP) has 34 core members representing four schools and 13 departments in total. During the current funding year, cancer-related funding for this program totaled $20.8M in total costs. Of this amount, peer-reviewed funding totaled $13.5M in total costs, including $3.4M from the National Cancer Institute. As with other programs, JCCC fosters a number of interactive activities and shared resources that support investigators in HARP. During the current grant cycle, funds from the JCCC in the form of the CCSG Developmental Funds, institutional support and philanthropic gifts to HARP total $2,043,085. These funds supported seed grants, program area leadership support, as well as the annual disparities symposium hosted by HARP in the community. The HARP program is highly interactive, with 15% of its publications reflecting intra-programmatic efforts and 11 % reporting inter-programmatic collaborations. 178 (28%) appeared in high-impact journals. Accruals to prevention trials totaled 1,186, screening 1,021, early detection/diagnostic 1,151, epidemiologic/obs/outcome 1,426, correlative 113. The goals of the HARP are to advance understanding of cancer risk and protective factors and to identify strategies to make the latest cancer prevention knowledge and technologies accessible to the population at large. HARP research spans four broad focus areas: 1. cancer risk and protective factors/etiology, 2. primary prevention, 3. screening/early detection, 4. infrastructure projects supporting community engagement. Two major themes characterize the research of this program: cancer disparities and translational research (mainly T3 and T4). These themes are not mutually exclusive, and in fact most projects in the program incorporate both. Our cancer disparities research focuses on cancer prevention and control interventions to mitigate disparities in low-income, ethnic minority and other socially and medically underserved populations in Los Angeles and beyond and has brought recognition to UCLA as one of the premier cancer disparities research programs in the nation.