Metabolic Skeletal Disorders Training Program Grant

描述(由申请人提供)：华盛顿大学医学院及其附属巴恩斯-犹太医院在肌肉骨骼研究、患者护理、教育和培训方面有着悠久的卓越传统。在过去的40年里，由骨和矿物疾病分部的成员和来自其他分部和科室的相关研究人员组成的广泛的骨生物学计划为致力于矿物质代谢疾病和骨骼疾病的研究人员和临床医生提供了机构和人力资源支持。矿物和骨骼代谢培训助学金AR007033连续资助了30多年，直到2004年，它一直是完成我们的教学使命的基础。在这项新的建议中，我们寻求重新建立一个跨学科的机构代谢性骨骼疾病培训计划(MSDTP)，以指导和培训下一代科学家和临床医生-科学家的骨骼研究，建立在我们机构的人才深度的基础上。该计划将提供5个主题领域的博士后和博士后培训：1)成骨谱系生物学；2)破骨细胞生物学和炎症性骨骼疾病；3)转移性骨骼疾病；4)骨骼发育和修复；5)骨骼疾病遗传学。这些主题代表了参与本次培训计划的教师的重点，并反映了每个研究小组的共同兴趣和互动。为本次MSDTP选择的P受体来自华盛顿大学的5个学术部门(内科、整形外科、病理学和免疫学、发育生物学和解剖学和神经生物学)，反映了广泛的研究兴趣，包括骨骼发育、成骨细胞、破骨细胞和软骨细胞生物学、细胞信号、干细胞和结构生物学、骨免疫和造血系统相互作用、生物力学、异位钙化以及小鼠和人类遗传学、骨转移和炎性骨溶解。培训将由4个部分组成：1)指导研究培训；2)核心课程课程；3)职业发展课程；4)陈述和报告技能。博士后培训计划将提供基础科学或以翻译/临床为导向的途径。博士前培训课程将与生物和生物医学科学部(DBBS)管理的博士和MD/博士项目整合在一起，DBBS管理华盛顿大学的研究生项目。精简但有重点的行政结构将管理受训人员的招聘、任命和进展，并监测计划的成功。该计划建立在强有力的跨部门和全校支持的基础上，将利用现有的机构基础设施，如骨和矿物病部门(用于资源和设施)，DBBS(用于实习生招募和课程工作)，以及翻译和临床科学研究所(用于核心、服务和正式培训)。培训下一代医生和科学家对于骨骼生物学研究的持续增长至关重要。这项研究对于了解骨骼疾病的遗传和分子基础，以及为骨质疏松、炎症性骨溶解、骨关节炎、肌腱衰竭和骨转移等疾病制定新的治疗策略是必要的，这些疾病困扰着很大一部分老年人。

DESCRIPTION (provided by applicant): Washington University School of Medicine and the affiliated Barnes-Jewish Hospital have a long tradition of excellence in musculoskeletal research, patient care, education and training. During the past 40 years, a broad program in bone biology consisting of members of the Division of Bone and Mineral Diseases and associated investigators from other Divisions and Departments have provided the institutional and human resources in support of investigators and clinicians committed to diseases of mineral metabolism and skeletal disorders. A Mineral and Skeletal Metabolism Training Grant, AR007033, was continuously funded for more than 3 decades, and until 2004, was fundamental to accomplishing our teaching mission. In this new proposal, we seek to re-establish an interdisciplinary, institutional Metabolic Skeletal Disorders Training Program (MSDTP) to mentor and train the next generation of scientists and clinician-scientists in skeletal research, building upon the depth of talent at our institution. This program will offer pre- and post-doctoral training in 5 thematic areas: 1) Biology of the osteogenic lineage; 2) Osteoclast biology and inflammatory skeletal disorders; 3) Metastatic bone disease; 4) Skeletal development and repair; 5) Genetics of skeletal disorders. These themes represent the focus of the faculty participating in this training program and reflect common interests and interactions within each research group. The pool of Preceptors selected for this MSDTP are drawn from 5 academic Departments at Washington University (Internal Medicine, Orthopaedic Surgery, Pathology and Immunology, Developmental Biology, and Anatomy and Neurobiology) and reflects broad research interests, including skeletal development, osteoblast, osteoclast and chondrocyte biology, cell signaling, stem cell and structural biology, bone-immune and hematopoietic system interactions, biomechanics, ectopic calcification, as well as mouse and human genetics, bone metastasis and inflammatory osteolysis. The training will consist of 4 components: 1) mentored research training; 2) core curriculum coursework; 3) career development coursework; 4) presentation and reporting skills. The post-doctoral training program will offer either a basic science- or a translational/clinical- oriented pathway. The pre-doctoral training pathway will be integrated with the PhD and MD/PhD programs administered by the Division of Biology and Biomedical Sciences (DBBS), which manages the graduate programs at Washington University. A streamlined but focused administrative structure will manage trainee recruitment, appointment and progress and monitor the program success. The program, which builds on strong interdepartmental and School-wide support, will leverage on existing institutional infrastructure, such as the Division of Bone and Mineral Diseases (for resources and facilities), the DBBS (for trainee recruitment and coursework), and the Institute for Translational and Clinical Sciences (for cores, services and formal training). Training the next generation of physicians and scientists is paramount to the continuous growth of research on skeletal biology. Such research is necessary to understand the genetic and molecular bases of skeletal disorders, and to devise new treatment strategies for diseases such as osteoporosis, inflammatory osteolysis, osteoarthritis, tendon failure, and bone metastasis, which afflict a large proportion of the elderly population.