Institutional Collaboration between LSTM and CDC and Prevention on Malaria(U01)

描述(申请人提供)：本提案概述了疾病控制和预防中心(CDC)疟疾分部和利物浦热带医学院(LSTM)疟疾流行病学组之间的持续合作，以支持疟疾流行国家的CDC合作伙伴开展合作研究，以改善非洲和印度尼西亚的疟疾控制，并协调疟疾控制的国际研究倡议。LSTM代表妊娠期疟疾(MIP)联盟，将协调CDC与欧洲、澳大利亚和流行国家的其他国际合作伙伴之间的研究战略制定，以便今后研究控制妊娠期疟疾。此外，LSTM、CDC和CDC在印度尼西亚(雅加达艾伊克曼研究所)和肯尼亚西部(KEMRI-CDC实地站)的海外合作伙伴将联合开展一系列研究项目。根据最初呼吁的大纲，这些目标分为三个主要目标：疟疾控制；孕期疟疾；以及综合疾病控制。有几个项目是从第一年开始的，反映了作为LSTM和CDC疟疾处之间现有合作协定(COAG)的一部分的联合活动的延伸。这些活动包括在肯尼亚西部开展一项研究，以开发工具监测妊娠早期抗疟疾药物的安全性，并对一种新的快速评估工具包进行评估，该工具包用于评估孕期疟疾干预措施的获取、提供和使用情况；在非洲进行了一项多国观察性研究，以确定磺胺多辛-乙胺嘧啶抗药性对孕期间歇预防治疗(IPTp)效果的影响；在印度尼西亚进行了两项研究：a)一项研究，其目的是评估印度尼西亚偏远地区乡村保健工作者利用手机技术改善疟疾监测的情况；B)评价在偏远地区控制孕期疟疾的快速诊断试验(RDT)的表现。此外，将在第1年和第2年编写赠款提案，为第2至第5年计划的活动提供研究资金，包括研究综合疾病控制方法，将艾滋病毒筛查与疟疾、梅毒和贫血的定期筛查结合起来，并使用间歇性筛查和孕期疟疾治疗。在COAG期间，LSTM将根据要求向疾病预防控制中心提供技术支持，以进行感染艾滋病毒的成人、儿童(基于年龄的剂量)和孕妇(甲氯喹)的特定药代动力学研究。最后，这些活动包括对个人的正式博士培训和临床试验方法学的短期培训。LSTM还将继续向世界卫生组织(世卫组织)和减少疟疾组织提供技术咨询，以支持在全球范围内扩大疟疾控制干预措施。

DESCRIPTION (provided by applicant): This proposal outlines continued collaboration between the Malaria Branch of the Centers for Disease Control and Prevention (CDC) and the Malaria Epidemiology Section of the Liverpool School of Tropical Medicine (LSTM) to support CDC partners in malaria endemic countries in the conduct of collaborative research to improve the control of malaria in Africa and in Indonesia and to coordinate international research initiatives for malaria control. LSTM, on behalf of the Malaria in Pregnancy (MiP) Consortium, will coordinate research strategy development between CDC and other International partners in Europe, Australia and endemic countries for future studies of the control of malaria in pregnancy. In addition, a range of research projects will be conducted jointly between LSTM, CDC and the overseas partners of CDC in Indonesia (the Eijkman Institute, Jakarta) and in western Kenya (KEMRI-CDC field station). These fall under three main objectives: malaria control; malaria in pregnancy; and integrated disease control, following the outline of the original call. Several projects start in year 1 and reflect an extension of the joint activities as part of the existing cooperative agreement (CoAg) between LSTM and CDC's Malaria Branch. These include a study to develop tools to monitor antimalarial drug safety in early pregnancy and a survey to evaluate a new rapid assessment toolkit for the evaluation of access, delivery and use of interventions for malaria in pregnancy, both in western Kenya; the central coordination of a multi-country observational study in Africa to determine the effect of sulfadoxine-pyrimethamine (SP) resistance on intermittent preventive treatment in pregnancy (IPTp) effectiveness, and two studies in Indonesia: a) a study evaluating the use of cell-phone technology to improve malaria surveillance by village based health-care workers in remote settings in Indonesia; b) evaluation of the performance of rapid diagnostic tests (RDTs) for the control of malaria in pregnancy in remote settings. In addition, grant proposals will be written in years 1 and 2 to generate research funds for the activities planned in years 2-5, including studies of integrated approaches to disease control which combine screening for HIV with scheduled screening for malaria, syphilis and anemia, and use of intermittent screening and treatment of malaria in pregnancy. During the course of the CoAg, LSTM will provide technical support to CDC as requested for specific pharmacokinetic studies in HIV- infected adults, in children (age-based dosing) and in pregnant women (Mefloquine). Lastly, the activities include formal PhD training of individuals and short-term training in clinical trial methodology. LSTM will also continue to provide technical advice to the World Health Organization (WHO) and Roll Back Malaria (RBM) in support of scaling up of malaria control interventions globally.