Interferon Regulatory Factor 6: a novel epithelial-specific regulator of mucosal inflammation

呼吸道和胃肠道的上皮细胞在保护我们免受感染方面起着关键作用。上皮细胞释放的炎症因子对抵抗感染很重要；然而，它们也会导致慢性炎症性疾病。我们的目标是了解一种名为IRF6的蛋白质如何调节上皮细胞的炎症反应。所获得的知识将确定炎症性疾病的新治疗方法。

Epithelial cells lining the respiratory and gastrointestinal tracts play pivotal roles in protecting us from infection. Inflammatory factors released by epithelial cells are important for fighting infection; however, they also contribute to chronic inflammatory diseases. We aim to understand how a protein called IRF6 regulates the inflammatory response of epithelial cells. The knowledge gained will identify new therapeutic approaches for inflammatory diseases.