Cannabinoid regulation of cognition

描述（由申请人提供）：大麻仍然是美国使用的最受欢迎的非法精神药物。大约70- 80%的40- 50岁的人在他们的一生中至少尝试过一次，18-21岁的人中有18- 19%在过去的一个月里使用过大麻。在美国，符合大麻依赖标准的人比过去一个月吸食可卡因或尝试过海洛因的人还要多；进一步令人关切的是，随着药房的激增，根据医用大麻法律使用大麻的情况在美国继续扩大。医疗使用增加的趋势可能会继续，例如，吸烟大麻或大麻素混合喷雾剂可以改善多发性硬化症的症状。研究表明，急性大麻中毒会损害认知功能，然而，某些大麻品种的成分大麻二酚（CBD）可能提供一些保护，免受大麻的急性和持久有害影响。该项目的研究试图确定CBD是否可以减轻d9 -四氢大麻酚（THC）引起的特定认知中断，使用非人类灵长类动物模型。一系列对四氢大麻酚敏感的测试将被用来确定CBD是否能阻断四氢大麻酚急性和慢性服用的影响。目的是确定CBD在多大程度上可以缓解治疗环境中四氢大麻酚的影响，尽管对娱乐性使用者也有影响。

DESCRIPTION (provided by applicant): Cannabis remains the most popular illicit psychoactive drug used in the US. Some 70-80 percent of 40- 50 year olds have tried it at least once in their lifetime and 18-19 percent of 18-21 years olds have used cannabis in the past month. There are more people in the US who meet criteria for cannabis dependence than have used cocaine in the past month or ever tried heroin; it is of further concern that the use of cannabis under medical marijuana laws continues to expand in the US as dispensaries proliferate. Trends for increased medical use may continue following, e.g., findings that smoked marijuana or a combined-cannabinoid spray can improve symptoms in multiple sclerosis. Studies have shown that acute intoxication with cannabis impairs cognitive function, however cannabidiol (CBD), a constituent of some cannabis strains, may provide some protection from the acute and lasting detrimental effects of cannabis. The studies in this project seek to determine if CBD can attenuate specific cognitive disruptions caused by D9-tetrahydrocannabinol (THC), using a nonhuman primate model. A battery of tests shown sensitive to THC will be used to determine if CBD can block the effects of both acute and chronic administration of THC. The goal is to determine the extent to which CBD might be used to moderate effects of THC in the therapeutic setting, although there are also implications for the recreational user.