Northwestern University Skin Disease Research Core Center

描述(由申请人提供)：西北大学(NU)以其强大的跨学科皮肤生物学研究项目而被公认。国家发改委拥有73名成员，包括14个大学系和医学系内的7个司，在维持和扩大这一研究计划方面发挥了重要作用。西北大学SDRC的目标一直是，并将继续促进皮肤生物学方面的杰出转化研究，最终改善患者护理。为了实现这一目标，国家发改委拥有以下核心：(I)管理；(Ii)皮肤组织工程；(Iii)形态和表型；以及(Iv)DNA/RNA传递。管理核心通过其丰富计划鼓励60个SDRC BASE研究成员和13个临床合作者协会成员之间的合作。在充实计划中，国家发改委将继续支持非常成功的试点和可行性(P&F)计划，该计划为国家发改委带来了新的成员，并开辟了皮肤生物学的新研究领域。行政核心将进一步扩大其成功的少数群体和性别意识方案，通过支持两个新的研究领域，侧重于更好地了解肤色和性别的皮肤差异。皮肤组织工程核心提供角质形成细胞，包括器官培养，并将扩展这项服务，以提供成纤维细胞、黑素细胞、患者皮损皮肤细胞，以及皮肤病的器官培养模型。形态和表型鉴定核心除了提供形态发生处理服务、激光捕获显微解剖能力和测试对人体皮肤渗透的测试外，还提供一个基础广泛的组织库。DNA/RNA递送核心产生慢病毒和逆转录病毒结构，以过度表达或沉默基因，并在皮肤细胞中表达报告。所有三个研究核心都通过培训和对结果的解释来提供教育，并有很强的翻译部分。国家发改委与NU Core的几个机构合作，为用户提供将他们的基本发现应用于临床的机会，从而定位自己在理解和治疗皮肤病方面取得重要进展。

DESCRIPTION (provided by applicant): Northwestern University (NU) is recognized for its strong interdisciplinary cutaneous biology research program. The SDRC, with its 73 members, encompassing 14 university departments and 7 divisions within the Department of Medicine, has played a major role in maintaining and expanding this research program. The goal of the Northwestern University SDRC has been and will continue to be the promotion of outstanding translational research in cutaneous biology, ultimately to improve patient care. To accomplish this goal, the SDRC has the following Cores: (i) Administration; (ii) Skin Tissue Engineering; (iii Morphology and Phenotyping; and (iv) DNA/RNA Delivery. The Administrative Core encourages collaboration among the 60 SDRC Bench Research members and the 13 Clinical Collaborator Associate members through its Enrichment Program. Within the Enrichment Program, the SDRC will continue to support the highly successful Pilot and Feasibility (P&F) Program, which has brought new members into the SDRC and opened novel areas of research in cutaneous biology. The Administrative Core will further expand its successful Minority and Gender Awareness Program, through the support of two new research areas focusing on understanding better the cutaneous differences in skin of color as well as gender. The Skin Tissue Engineering Core provides keratinocytes, including organotypic cultures, and will extend this service to offer fibroblasts, melanocytes, cells from patient lesional skin, and organotypic culture models of skin disease. The Morphology and Phenotyping Core offers a broad-based tissue bank, in addition to its morphogenetic processing services, laser capture micro-dissection capabilities, and assays to test penetration into human skin. The DNA/RNA Delivery Core generates lentiviral and retroviral constructs to overexpress or silence genes, and to express reporters in skin cells. All three Research Cores provide education through training and interpretation of results and have strong translational components. The SDRC has partnered with several NU Core facilities to provide users with opportunities to take their basic findings into a clinical setting, thus positioning itself to make important strides in understanding and treating diseases of the skin.