Training Program in Cellular, Biochemical, and Molecular Sciences

描述（由申请人提供）：本申请要求支持在托马斯杰斐逊大学的细胞，生物化学和分子科学的博士前培训计划。该计划为学生提供广泛的多学科培训，使用生物化学，细胞和分子策略来解决重要的生物学问题。该计划中的所有导师都建立了研究计划和重要的指导经验。具体的培训领域包括生长因子，G蛋白偶联和核受体信号传导，信号整合，蛋白质靶向和运输，细胞周期调控，细胞凋亡， 转录和DNA修复。正在进行的研究项目涉及这些领域对正常功能以及疾病过程和治疗发明的重要性。此外，相当多的导师在他们的研究中使用动物模型和转化方法。参与教师的这种独特组合将通过课程工作，直接指导互动，专业教育活动，研讨会和半年一次的务虚会提供培训。 细胞，生物化学和分子科学的培训计划包括来自7个基础和临床部门的25名导师，并由主要研究者和行政委员会管理。领导小组的重点是向来自不同种族和科学背景的受训人员提供优质培训。该计划将通过内部和外部审查机制进行评估，以确保受训人员获得最佳培训体验。总的来说，该计划将为学员提供出色的职业发展，使他们能够依靠知道如何使用机械方法来解决重要的科学问题来追求职业生涯，并将在使用动物模型和转化方法来了解疾病的多学科性质方面提供关键的团队教育经验。

DESCRIPTION (provided by applicant): This application requests support for a predoctoral Training Program in Cellular, Biochemical and Molecular Sciences at Thomas Jefferson University. This Program provides students with broad multidisciplinary training in using biochemical, cellular and molecular strategies to address important biological questions. All mentors in this program have established research programs and significant experience in mentoring. Specific training areas include growth factor, G protein-coupled and nuclear receptor signaling, signal integration, protein targeting and trafficking, cell cycle regulation, apoptosis, transcription and DNA repair. Ongoing research projects address the importance of these areas to normal functioning as well as to disease processes and therapeutic inventions. In addition, a significant number of the mentors use animal models and translational approaches in their research. This unique combination of participating faculty will provide training through course work, direct mentoring interactions, specialized educational activities, seminars and semi-annual retreats. The Training Program in Cellular, Biochemical and Molecular Sciences includes 25 mentors from 7 basic and clinical departments and is administered by the Principal Investigator and Administrative Committees. The leadership team is focused on delivering training excellence to an ethnically and scientifically diverse cadre of trainees. The program will be evaluated through both internal and external review mechanisms to ensure that the trainees are receiving the best possible training experience. Overall, this Program will provide outstanding career development for trainees to pursue careers dependent on knowing how to use mechanistic approaches to address important scientific questions and it will provide a critical team educational experience in the multidisciplinary nature of using animal models and translational approaches to understand disease.