Aspergillus Genome Database

描述(由申请人提供)： 曲霉属含有条件致病菌烟曲霉菌和遗传模型烟曲霉菌。在世界各地发现的烟曲霉是人类侵袭性霉菌感染的最常见原因，也是致病真菌中人类死亡人数最多的原因。重要的是，即使接受治疗，死亡率仍然保持在至少50%。令人担忧的是，非烟曲霉菌感染也在上升。事实上，据报道有20多种曲霉引起曲霉病，从过敏和鼻窦炎到危及生命的侵入性感染等一系列疾病。曲霉基因组数据库(AspGD)包含曲霉的准确基因组序列、衍生特征和最新的基于文献的基因和蛋白质信息。AspGD已经成为真菌研究界成员不可或缺的资源，使他们能够充分利用他们的集体研究努力，并加速发现。公开的曲霉菌基因组序列比任何其他真菌属都多，包括酵母菌和念珠菌。随着它的医学相关性和实验可操作性，这种丰富的基因组序列使曲霉成为比较基因组研究的首选真菌物种。这项更新建议的目标是通过在比较基因组学框架中将高质量的文献整理与尽可能最好的初级基因组注释结合起来，继续为曲霉研究社区服务。我们将充分利用目前正在生成和发布的海量高通量数据，对参考序列进行改进，并完善基因组中基因的注释。此外，我们将为用户提供直观地查询、比较和可视化这些数据的能力。通过这种方式，我们将帮助加快对曲霉的研究，使研究人员能够访问与高通量数据集并列的相关注释信息。为维护和扩大经过精心管理的曲霉公共数据库而分配的资源将继续加速曲霉研究，这样做将有助于对抗烟曲霉和非烟曲霉菌感染，从而对人类健康产生重大积极影响。

DESCRIPTION (provided by applicant): The genus Aspergillus contains the opportunistic pathogen, A. fumigatus, as well as the genetic model A. nidulans. Aspergillus fumigatus, found throughout the world, is the most common cause of invasive mold infections in humans and is responsible for the highest number of human deaths among pathogenic fungi. Importantly, even with treatment, mortality still remains at least 50%. Of concern is the fact that non-fumigatus Aspergillus infections are also on the rise. Indeed, over two dozen Aspergillus species have been reported to cause aspergillosis, a collection of conditions that ranges from allergy and sinusitis to life-threatening invasive infection. The Aspergillus Genome Database (AspGD) contains accurate genome sequence, derived features and up-to-date literature-based gene and protein information for Aspergillus species. AspGD has become an indispensible resource for members of the fungal research community, enabling them to take full advantage of their collective research efforts, and to accelerate discovery. There are more Aspergillus genome sequences publicly available than there are for any other fungal genus, including Saccharomyces and Candida. Along with its medical relevance and experimental tractability, this wealth of genomic sequences makes the Aspergilli the premiere fungal species for comparative genomic studies. The goal of this renewal proposal is to continue to serve the Aspergillus research community by integrating high quality literature curation with the best possible primary genome annotations in a comparative genomics framework. We will take full advantage of the deluge of high-throughput data that are now being generated and published to make improvements to reference sequences, and to refine the annotation of genes within the genomes. Furthermore, we will provide users with the ability to query, compare and visualize these data intuitively. In this way, we will help to accelerate research into the Aspergilli, by enabling researchers to access relevant annotation information juxtaposed with high- throughput datasets. The allocation of resources to maintain and expand a carefully curated Aspergillus public database will continue to accelerate Aspergillus research, and in doing so will aid in the fight against A. fumigatus and non-fumigatus Aspergillus infections, and thus significantly positively impact human health.