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Interplay between metabolic reprogramming and oncogenic signalling in the cellular response to chemotherapy

Interplay between metabolic reprogramming and oncogenic signalling in the cellular response to chemotherapy
细胞化疗反应中代谢重编程与致癌信号之间的相互作用
批准号:
nhmrc : GNT1146642
负责人:
Dr Kristin Brown
金额:
$64.5万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --

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中文摘要
翻译
化疗耐药是三阴性乳腺癌治疗的主要障碍。我们试图揭示细胞新陈代谢和致癌信号通路之间的密切联系,以调节细胞对化疗的反应。我们的研究将确定限制化疗疗效的关键机制,并研究可以改善TNBC治疗的联合治疗策略。
英文摘要
Chemotherapy resistance is a major barrier to the treatment of triple-negative breast cancer (TNBC). We seek to uncover an intimate link between cell metabolism and oncogenic signalling pathways in regulating the cellular response to chemotherapy. Our studies will identify a critical mechanism limiting the therapeutic efficacy of chemotherapy and investigate combination therapy strategies that could improve the treatment of TNBC.
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