Interplay between mutant p53 and PML; implications for tumourigenesis.
Interplay between mutant p53 and PML; implications for tumourigenesis.
批准号:
nhmrc : 509197
负责人:
Prof Ygal Haupt
金额:
$32.26万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2011-12-31
中文摘要
身体对抗癌症的最重要的代理商是细胞蛋白质p53。在超过50%的人类癌症中,它通过突变失去了抗癌特性。这种新的突变形式以一种阴险的方式促进癌症的发生。为了更好地治疗癌症,我们需要了解突变型p53的功能。我们将研究它如何与癌细胞中的分子伴侣相互作用。
英文摘要
The most important agent of the body for fighting cancer is the cellular protein p53. In more than 50% of all human cancers, it looses its anticancer properties through mutation. In an insidious manner this new mutant form then acts to promote cancer. To better treat cancer we need to understand how mutant p53 functions. We will study how it interacts with its molecular partners in cancer cells.
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会议论文
A novel role for E6AP in cellular senescence
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批准号:nhmrc : 1026990
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项目类别:Project Grants
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资助金额:$34.16万
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财政年份:2012
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负责人:Prof Ygal Haupt
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依托单位:
Research Fellowship
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批准号:nhmrc : 628426
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项目类别:NHMRC Research Fellowships
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资助金额:$52.72万
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财政年份:2010
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负责人:Prof Ygal Haupt
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依托单位:
Regulation of PML by E6AP: implications for tumour development.
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批准号:nhmrc : 509196
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项目类别:NHMRC Project Grants
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资助金额:$35.86万
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财政年份:2008
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负责人:Prof Ygal Haupt
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依托单位:
海外基金