A novel role for E6AP in cellular senescence

E6AP 在细胞衰老中的新作用

• 批准号: nhmrc : 1026990
• 负责人: Prof Ygal Haupt
• 金额: $ 34.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-role-e6ap-cellular-senescence/110533
• 关键词: novel; role; E6AP; cellular; senescence

Cancer is constantly being suppressed in our bodies by a process that stops damaged cells from growing: 'senescence'. The mechanism that translates the damage stimuli into this state of permanent cell arrest is only partially known. We have identified a protein that appears to drive this restraint. The possibility of manipulating this process to prevent and cure cancer makes it in important target to study.

癌症在我们的身体中不断被一个阻止受损细胞生长的过程所抑制：“衰老”。将损伤刺激转化为这种永久性细胞停滞状态的机制仅部分已知。我们已经确定了一种蛋白质，似乎驱动这种限制。操纵这一过程以预防和治疗癌症的可能性使其成为重要的研究目标。