Regulation of PML by E6AP: implications for tumour development.

E6AP 对 PML 的调节：对肿瘤发展的影响。

• 批准号: nhmrc : 509196
• 负责人: Prof Ygal Haupt
• 金额: $ 35.86万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-pml-e6ap-tumour-development/95364
• 关键词: Regulation; PML; E6AP; implications; tumour

PML is a vital tumour suppressor, but little is known about its regulation. We established that PML levels are affected by another cellular protein E6AP. This study will define the mechanism by which E6AP influences PML. Human cancers will be screened for the involvement of these proteins, to gain new insights into cancer onset. The intended practical outcome of these studies is to aid cancer diagnosis and provide new anti-cancer drugs.

PML是一种重要的肿瘤抑制因子，但对其调控知之甚少。我们确定PML水平受另一种细胞蛋白E6AP的影响。本研究将明确E6AP影响PML的机制。人类癌症将被筛选这些蛋白质的参与，以获得对癌症发病的新见解。这些研究的预期实际结果是帮助癌症诊断和提供新的抗癌药物。