The Cleveland Clinic Innovation Accelerator

克利夫兰诊所(CC)及其合作伙伴凯斯西部储备大学、辛辛那提儿童医院 医学中心、俄亥俄州立大学和辛辛那提大学长期致力于 在将实验室和临床创新转化为显著改进方面取得了有记录的成功 仅患者护理，CC就通过其商业化部门CC Innovation(CCI)产生了53个衍生产品 在过去十年中，公司和6.44亿美元的股权融资；然而，CCI专注于 成熟的项目，不会回到研究管道中。此外，还有助于商业化 申请机构的成功成立了国家资助的全球心血管 创新中心(GCIC)，其使命是推进晚期心血管创新，即 具有快速创造就业潜力的机会。申请者财团现已联合起来 通过提议建立一个新的中心(克利夫兰诊所创新加速器，CCIA)来解决未得到满足的需求 推动早期项目的总体目标，并教育研究人员成为 将他们的发现转化为对患者护理产生重大影响的进步。拟建的中心将加强 并协调五个合作机构的现有资源，以推进非常强大的 每年在NHLBI任务区产生的实验室发现和技术创新(超过250项 NHLBI资助的项目)。这个应用程序有三个具体目标：(1)创建CCIA-一个自我可持续的， 多机构联盟专注于将NHLBI任务区的早期创新转化为 转化为先进的解决方案，以改善全球患者护理。CCIA将通过以下方式补充GCIC的使命 更早地进入发现和开发管道，以解决发现之间的差距 研究和验证/临床前开发。(2)通过严格的同行评审选择具有商业前景的公司 NHLBI资助的项目将获得资金和专家项目管理。项目应跨越 诊断、设备、治疗和工具的技术范围。(三)打造全国通行的 教育和指导生物医学创新和开发人员、临床医生和开发人员的研究所 企业家精神。该中心将提供以经验为基础的培训，以培养不断成长的干部队伍 商业上成功的创新者。CCIA的产生将因此创建一个自我可持续的引擎 推动与NHLBI相关的一大批研究发现在人类健康方面取得进展。

Cleveland Clinic (CC) and its partners Case Western Reserve University, Cincinnati Children's Hospital Medical Center, The Ohio State University and University of Cincinnati have a longstanding commitment and documented success in transitioning laboratory and clinical innovations into dramatic improvements in patient care, CC alone, via its commercialization arm CC Innovations (CCI), has generated 53 spin-off companies and $644 million in equity financing in the past decade; however CCI has a focus on more mature programs and does not reach back into the research pipeline. Also, contributing to commercialization success of the applicant institutions has been the establishment of the state-funded Global Cardiovascular Innovation Center (GCIC) that has a mission of advancing late-stage cardiovascular innovations, i.e., "shovel ready" opportunities with rapid job creation potential. The applicant consortium has now come together to address an unmet need by proposing a new Center (Cleveland Clinic Innovation Accelerator, CCIA) with an overall goal of propelling early-stage projects forward and educating researchers to be full partners in transforming their discoveries into high-impact advances in patient care. The proposed Center will enhance and coordinate the existing resources of the five partnering institutions to advance the very strong pipeline of laboratory discoveries and technical innovations generated every year in NHLBI mission areas (over 250 NHLBI-funded projects). This application has three specifics aims: (1) To create the CCIA - a self-sustainable, multi-institutional consortium focused on translating early innovations in NHLBI mission areas into advanced solutions for improving global patient care. CCIA will complement the mission of the GCIC by reaching earlier into the discovery and development pipeline in order to address the gap between discovery research and validation/pre-clinical development. (2) To select through rigorous peer-review commercially-promising NHLBI funded projects that will receive funds and expert project management. Projects shall span the technology range of diagnostics, devices, therapeutics and tools. (3) To create a nationally accessible institute for educating and mentoring researchers, clinicians and developers in biomedical innovation and entrepreneurism. The Center will provide experience-based training to cultivate a growing cadre of commercially successful innovators. Generation of the CCIA will thus create a self-sustainable engine for propelling a large pipeline of NHLBI-related research discoveries into advances in human health.