Small Animal Cone Beam CT Guided X-Irradiation System (SARRP)

描述(由申请人提供)：这笔S10共享仪器赠款将用于购买由佐治亚州苏瓦尼的GulMay Medical，Inc.制造的锥束CT引导小动物辐射研究平台(SARRP)。迫切需要这种机器，它是一种临床前研究工具，用于对小动物(小鼠和大鼠)的研究，可以模拟在治疗环境中给予人类的暴露。尽管临床放射治疗的技术在过去的25年里有了显著的进步，但在实验室环境下进行放射治疗的方法却落后了。现代放射治疗使用图像引导，在保留正常组织结构的同时，将高度适形辐射输送到靶区。相比之下，动物研究中用于照射自发或原位肿瘤及其转移的方法仅受外部特征的指导，通常会使身体的大部分暴露在辐射之下。SARRP为翻译辐射生物学的临床前研究提供了一项强大的新技术。SARRP是便携式的，带有机载锥束CT成像(0.25-0.5 mm体素大小)来指导辐射传输。它可以以亚毫米精度向目标体积提供高度共形辐射。因此，它可以精确地照射动物，其精确度接近当前的临床实践。保留正常组织是必要的，因为 我们转向低分馏的治疗方案，以试验将其带到临床的方法。SARRP辐照器是基于约翰·霍普金斯大学辐射物理系主任John Wong博士开发的原型。王博士的仪器已经使用了七年，还有17台在美国和其他地方使用。王博士将担任我们小组的顾问。仪器的管理将由医用物理联合调查员和放射肿瘤学/放射生物学联合调查员负责。协助行政当局的是一个内部咨询委员会，该委员会在辐射生物学(PI)、医学物理学、放射肿瘤学、实验肿瘤学、核医学/放射药物化学(小动物成像设施主任)和细胞生物学/免疫学(金梅尔癌症中心主任共享资源，用于流式细胞术和Cs-137照射)方面表现出专业知识。分子辐射生物学分会是美国比较活跃的辐射生物学组织之一，非常重视转译研究。医学物理部在适形和立体定向治疗规划、在线图像融合和设置校正方面拥有专业知识，直接支持这种高端辐照器的使用。支持机器运行的资金将来自大学行政部门、医学院行政部门、基梅尔癌症中心和放射肿瘤学系以及使用费。我们有20名NIH资助的用户和5名非NIH研究资助的用户。杰斐逊在放射学、放射肿瘤学和放射生物学方面有着悠久的历史。收购这台最先进的机器将使我们的平移放射肿瘤学研究环境实现量子飞跃。

DESCRIPTION (provided by applicant): This S10 shared instrumentation grant will fund the purchase of a Cone Beam CT Guided Small Animal Radiation Research Platform (SARRP), manufactured by Gulmay Medical, Inc., Suwanee, GA. There is a critical need for this machine, which is a preclinical research tool for studies on small animals (mice and rats) that can model the exposures given to humans in therapeutic settings. Although the technology for clinical radiation therapy has advanced significantly in the past 25 years, the methods for radiation delivery in a laboratory setting have lagged behind. Modern radiotherapy uses image guidance to deliver highly conformal radiation to a target volume while sparing normal tissue structures. By contrast, methods used in animal research to irradiate spontaneous or orthotopic tumors and their metastases are guided by external features alone, and generally expose a large portion of the body to radiation. The SARRP offers a powerful new technology for preclinical studies in translational radiation biology. The SARRP is portable, with on-board cone beam CT imaging (0.25-0.5 mm voxel size) to guide radiation delivery. It can deliver highly conformal radiation to target volumes with sub-millimeter accuracy. As such, it can precisely irradiate animals with a level of precision that approaches current clinical practice. Sparing normal tissue is essential as we move towards hypofractionated treatment schedules to pilot approaches to bring to the clinic. The SARRP irradiator is based on the prototype developed by Dr. John Wong, Director of Radiation Physics, Johns Hopkins University. Dr. Wong's instrument has been in use for seven years, and there are 17 more in service in the USA and elsewhere. Dr. Wong will serve as a consultant for our group. Administration of the instrument will be by the PI, the Co-Investigator for Medical Physics and the Co-investigator for Radiation Oncology/Radiation Biology. Assisting the Administration is an Internal Advisory Committee with demonstrated expertise in radiation biology (PI), medical physics, radiation oncology, experimental oncology, nuclear medicine/ radiopharmaceutical chemistry (Director of the Small Animal Imaging Facility) and cell biology/immunology (Director of the Kimmel Cancer Center Shared Resources for Flow Cytometry & Cs-137 Irradiation). The Division of Molecular Radiation Biology is one of the more active radiation biology groups in the USA with a strong emphasis on translational research. The Medical Physics Division has expertise in conformal and stereotactic treatment planning, online image fusion and setup correction, which directly supports use of this high-end irradiator. Funds to support operation of the machine will come from the Administration of the University, the Medical College Administration, the Kimmel Cancer Center and the Department of Radiation Oncology and from user fees. We have 20 NIH-funded users and five users with non-NIH research funding. Jefferson has a long history of academic radiology, radiation oncology and radiation biology. The acquisition of this state-of-the-art machine will allow for a quantum leap forward for our translational radiation oncology research environment.