Developmental Determinants of Cardiovascular Disease

描述（由申请人提供）：这是一份新的T32申请，来自范德比尔特大学医学院儿科儿科心脏病科和范德比尔特Monroe Carell Jr.儿童医院。我们的长期目标是通过开发一个将心血管疾病发育决定因素研究的正式培训与儿科心脏病学的临床培训相结合的项目，在培训学术儿科心脏病专家方面取得成功。该培训计划不仅将重点放在先天性心脏病的分子和遗传病因上，还将强调产前和产后发育对确定出生后儿科心血管疾病表现的影响。除了儿科心脏病学的培训生外，相关儿科亚专科的临床研究员，如肺医学、重症医学和新生儿科，以及对研究心血管疾病的发展机制有兴趣的博士博士后研究员将有资格获得支持。该项目将为学员提供一个独特的机会，学习在儿童或成年后期出现的心血管病理的正常发育过程的重述。该计划将由两个优化轨道组成，分别为(1)基础科学调查或(2)临床或转化研究做准备。有针对性的教学互动的重点实验室经验将量身定制，以满足那些追求更基础的科学事业的需要。对于追求临床或转化医学职业生涯的受训者，范德比尔特临床研究理学硕士（MSCI）计划将是培训计划的一个组成部分。候选人将主要从儿科心脏病学奖学金的申请者中确定（2010年有102名申请者申请2个职位）。该提案将资助奖学金的第二和第三年，在此期间，受训者将进行指导的研究。在第四年，受训者将完成临床培训，选择亚专科的高级培训，以及继续研究和提交K08或K23申请。该部和司承诺为这一培训的第一年和第四年提供经费。项目主管将使用一个内部咨询委员会，该委员会由范德比尔特大学内成功的内科科学家组成，以及一个外部咨询委员会，该委员会包括临床和基础研究专家，他们也是目前T32在儿科心脏病学应用的项目主管。利用范德比尔特大学在发育生物学、血管生物学、再生医学和组织工程、心血管药理学和药物遗传学、人口和基于结果的研究等领域的独特优势，该项目将帮助培养下一代内科科学家。通过将以前的学员作为培训导师，该项目将帮助这些初级教师的学术生涯，并为该项目的未来成功保持一个骨干导师队伍。

DESCRIPTION (provided by applicant): This is a new T32 application from the Division of Pediatric Cardiology of the Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt. Our long- term goal is to build upon the success of the Division in training academic pediatric cardiologists by developing a program that integrates formal training in research on developmental determinants of cardiovascular disease with clinical training in pediatric cardiology. This training program will not only focus on the molecular and genetic etiologies of congenital heart disease, but will also emphasize the impact of pre- and postnatal development in defining the manifestations of pediatric cardiovascular disease after birth. In addition to trainees in the Pediatric Cardiology, clinical fellows in related Pediatric subspecialties such as Pulmonary Medicine, Critical Care Medicine, and Neonatology as well as Ph.D. post-doctoral fellows who have an expressed interest in investigating development mechanisms of cardiovascular disease will be eligible for support. This program will provide a unique opportunity for trainees to study the recapitulation of normal developmental processes in the ontogeny of cardiovascular pathology presenting later in childhood or adulthood. The program will be composed of two tracks optimized either for pursuit of preparation for (1) basic science investigation or (2) clinical or translational research. A focused laboratory experience with targeted didactic interactions will be tailored to meet the needs of those pursing a more basic science career. For trainees pursuing a career in clinical or translational medicine, the Vanderbilt Master of Science in Clinical Investigation (MSCI) program will be an integral part of the training program. Candidates will primarily be identified from the pool of applicants for pediatric cardiology fellowship (102 applicants for 2 positions in 2010). This proposal will fund the second and third years of fellowship, during which the trainee will carry out the mentored research. During the fourth year, the trainee will complete clinical training with the option of advanced training in a sub-subspecialty as well as continued research and submission of a K08 or K23 application. The Department and Division are committed to funding the first and fourth years of this training. The program directors will use an internal advisory committee, comprised of successful physician-scientists from within Vanderbilt, as well as an external advisory committee that includes experts in both clinical and basic research who are also program directors for current T32 applications in Pediatric Cardiology. Using the unique strengths of Vanderbilt University in the areas of developmental biology, vascular biology, regenerative medicine and tissue engineering, cardiovascular pharmacology and pharmacogenetics, and population as well as outcomes based research, the program will help train the next generation of physician scientists. By including former trainees as Mentors-in-training, the program will assist these junior faculty members in their academic careers as well as maintain a cadre of mentors for the future success of this program.