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Development of Pre-Erythrocytic Malaria Vaccines

Development of Pre-Erythrocytic Malaria Vaccines
前红细胞疟疾疫苗的开发
批准号：
8946601
负责人：
ROBERT A SEDER
金额：
$52.45万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8946601
关键词：
AdjuvantAntibodiesAreaAttenuatedBiological AssayBiteBloodCD4 Positive T LymphocytesClinical TrialsCulicidaeDevelopmentDoseDrug FormulationsErythrocytesGoalsHeterogeneityHumanImmuneImmunityImmunizationImmunologic AdjuvantsInfectionLiverMalariaMalaria VaccinesModelingMonoclonal AntibodiesMusPhasePhase I Clinical TrialsPreventiveProteinsRadiationRegimenRouteSamplingScheduleSpleenSporozoite vaccineSporozoitesT cell responseT-LymphocyteTherapeuticVaccinatedVaccinationVaccinesViral Vectorcircumsporozoite proteinimmunogenicityinsightresponse

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中文摘要
翻译
今年的主要发现如下。
英文摘要
The major discovery this year are as follows. 1. Initiated a phase I clinical trial assessing whether irradiated PfSPZ given by the IV or IM route is safe, and confers durable immunity and protection using various doses and intervals for immunization. 2. Characterized the sporozoite specific T cell and NK responses longitudinally following vaccination and infection to provide insights into the correlates of protection. Used Fluidigm to characterize the heterogeneity of the sporozoite specific CD4+ T cell response in vaccinated/protected versus vaccinated/unprotected or control infected subjects. 3. Isolated monoclonal antibodies against malaria specific proteins ( eg CSP) in vaccinated and protected subjects.
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会议论文
VACCINE DEVELOPMENT FOR TUBERCULOSIS
  • 批准号：
    7958684
  • 项目类别：
  • 资助金额：
    $5.57万
  • 财政年份：
    2009
  • 负责人：
    ROBERT A SEDER
  • 依托单位：
    TULANE UNIVERSITY OF LOUISIANA
DNA VACCINATION FOR PREVENTION OF VIRAL, PARASITIC AND MYCOBACTERIAL INFECTION
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