Southwest Environmental Health Sciences Center

描述(由申请人提供) 西南环境健康科学中心(SWEHSC)的使命是了解环境暴露对人类疾病风险的调节机制。这对于改善西南地区人民的生活这一长期目标至关重要，方法是制定合理的办法，减轻他们暴露在危险环境中的风险，并最大限度地保护他们的环境暴露。SWEHSC的地理位置，以及其丰富的西班牙裔和美洲原住民文化遗产，为基础环境健康科学研究提供了独特的机会，以影响这些少数群体的健康。此外，加强两国之间的联系 墨西哥北部的SWEHSC教职员工以及学术和政府机构将促进环境健康科学领域的两国倡议的加强，真正有能力改善美墨边境的公共健康。将研究人员的努力集中在干旱环境、疾病和西南地区常见的人身上，将使具有相似人口和环境的全球利益相关者得以广泛翻译。SWEHSC的研究是在主题范围内协调的。每个专题领域的领导人负责发展跨学科小组，旨在整合具有不同专业知识的调查人员，通过纳入调查人员环境健康科学哲学的关键要素，包括：一)以人/翻译为重点，二)界定保护性和有害的环境暴露，三)从国际角度看待环境问题，四)利用尖端技术进行系统级生物分析。SWEHSC包括4个主要科学主题：西南危险环境暴露(RFG1)、环境肺病(RFG2)、ROS与疾病预防(RFG3)以及暴露、命运和处置(RFG4)。SWEHSC的研究工作与四个设施核心(FC)相辅相成，提供最先进的仪器和专业知识，帮助研究人员开发和利用尖端技术：细胞成像、基因组学、蛋白质组学和综合健康科学设施核心。行政核心提供丰富方案，包括研讨会、研讨会、年度科学博览会、通讯，并支持内部和外部咨询委员会的活动。SWEHSC还通过试点项目方案以及在招募新的调查人员方面促进创新研究。职业发展核心为初级研究人员提供指导，并在当前技术方面对研究人员进行交叉培训，以加强研究员和临床医生的环境健康科学研究计划，并为建立人体研究的长凳研究人员提供指导。社区推广和教育核心(COEC)通过翻译和传播SWEHSC科学家的研究成果，支持SWEHSC的社区参与使命。在接下来的五年里，SWEHSC将继续将基础环境卫生科学研究扩展到公共卫生和临床领域。这种“转化性”举措是SWEHSC目标不可或缺的一部分。

DESCRIPTION (provided by applicant) The mission of the Southwest Environmental Health Sciences Center (SWEHSC) is to understand the mechanisms behind the modulation of human disease risk by environmental exposures. This is essential to the long-term goal of bringing an improvement to the lives of the people of the Southwest by developing rational approaches to mitigating their risks of hazardous environmental exposures and by maximizing their protective environmental exposures. The geographic location of the SWEHSC, with its rich Hispanic and Native American cultural heritage, provides unique opportunities for basic environmental health sciences research to impact the health of these minority populations. Moreover, the strengthening of ties between SWEHSC faculty and academic and governmental agencies in northern Mexico will facilitate the enhancement of bi-national initiatives in the environmental health sciences, with the real ability to improve public health along the U.S./Mexico border. Focusing the investigators' efforts on arid environment, diseases, and people common to the Southwest will allow broad translation to global stakeholders with similar populations and environments. Research at SWEHSC is coordinated within themes. Leaders of each thematic area have been charged with developing interdisciplinary groups aimed at integrating investigators with diverse expertise to produce environmental health deliverables through the incorporation of key elements of the investigators' philosophy for environmental health science, including i) a human/translational focus, ii) defining protective as well as harmful environmental exposures, iii) viewing environmental problems through an international perspective, and iv) utilizing cutting edge technology to enable systems-level biological analysis. The SWEHSC embraces 4 major scientific themes: Southwest Hazardous Environmental Exposure (RFG1), Environmental Lung Diseases (RFG2), ROS and Disease Prevention (RFG3), and Exposure, Fate, and Disposition (RFG4). The research efforts of SWEHSC are complemented by four Facility Cores (FC) offering state-of-the-art instrumentation and expertise to assist investigators in developing and utilizing cutting-edge technologies: Cellular Imaging, Genomics, Proteomics, and Integrative Health Sciences Facility Core. The Administrative Core provides enrichment programs, including seminars, workshops, an annual Science Fair, newsletters, and supports the activities of the Internal and External Advisory Boards. The SWEHSC also promotes innovative research through the Pilot Project Program, and in the recruitment of new investigators. The Career Development Core provides mentoring to junior investigators and cross-training of researchers in current techniques to enhance the environmental health science research programs of fellows and clinicians, and for bench researchers establishing human studies research. The Community Outreach and Education Core (COEC) supports the SWEHSC mission of community involvement by translating and disseminating the research findings of SWEHSC scientists. During the next five years SWEHSC will continue to extend basic environmental health sciences research into the public health and clinical arenas. Such "translational" initiatives are integral to the goals of SWEHSC.