NIDDK Genetics Repository

疾病相关基因的发现需要一个具有遗传变异的个体群体，以及一个对照(未受影响的)个体群体。因此，遗传物质的储存库，包括DNA样本、冷冻保存的淋巴细胞、永生化细胞系，以及伴随的临床和谱系数据，显然是研究与NIDDK任务有关的疾病的研究界的宝贵资源。这个项目在这里将被称为遗传学资料库，延续了2003年开始的一项重要收藏，在概念上与美国国立卫生研究院其他研究所现有的资料库有关。该储存库将允许继续储存、维护和质量控制，以及公平、合乎道德地分配DNA和其他对NIDDK授权下的疾病研究重要的资源。它促进了资源的共享，从而鼓励了广泛的研究人员的工作，并可能增加样本规模和研究结果的力量，以确定一种疾病的遗传决定因素。它有助于确保研究参与者做出最大贡献，并减少重复的抽样工作。

Discovery of disease related genes requires a population of individuals with the genetic variant, as well as a population of control (unaffected) individuals. Thus, a repository of genetic materials, including DNA samples, cryopreserved lymphocytes, immortalized cell lines, and accompanying clinical and pedigree data is clearly an invaluable resource for the research community studying diseases related to the mission of the NIDDK. This project, which will be referred to herein as ¿The Genetics Repository¿, continues an important collection begun in 2003 and is conceptually related to repositories in existence at other institutes at the NIH. The repository will allow the continued storage, maintenance, and quality control, and equitable, ethical distribution of DNA and other resources important to the study of diseases under the mandate of the NIDDK. It facilitates sharing of resources, thus encouraging work by a broad group of investigators and, perhaps, increasing the sample size and the resulting power of a study to identify genetic determinants of a disease. It helps to ensure that research participants will be making a maximal contribution, and decreases duplicative sampling efforts.