Health Sciences Center Animal Resource Facility Improvement

描述（由申请人提供）：这项名为“新墨西哥大学健康科学中心动物资源设施改善”的G20提案的目的是申请499,967美元，用于：1)支持购买25个带有笼子/附件的通风鼠架和相关的机械和电气结构，以便将这些单元连接到5个SPF老鼠房间中的4个房间的建筑排气和电气（第5个房间位于老鼠繁殖屏障内，最近翻新时安装了连接）（1261平方英尺/ 1159平方英尺）。2)升级SPF小鼠研究套房的2个手术室（399平方英尺/ 352平方英尺），拆除旧的，增加新的病例工作，并在其中一个手术室购买一个5英尺高的HEPA过滤动物手术站。受此项目影响的总空间为1,660平方英尺/ 1,511平方英尺，其中包括新墨西哥大学（UNM）健康科学中心（HSC）动物资源设施（ARF）的设备放置和/或翻新空间。该ARF项目位于生物医学研究设施（BRF）和基础医学科学大楼（BMSB）的连续空间内。BRF/BMSB动物设施是ARF的主要组成部分，但HSC ARF还包括两个HSC卫星成像设施的住房/研究。该项目是在2002年、2008年和2013年在BRF和BMSB ARF完成的三个改造项目的基础上进行改进的。这些过去的翻新升级了机械（带有DDC控制和环境警报的暖通空调）、地板、饰面和屋顶，最近的项目（2012年G20奖励50万美元加上82K美元的机构匹配）更换了一台26年的隧道洗衣机，翻新了4个房间，并在老鼠饲养围栏的4个房间中的3个房间增加了16个通风老鼠架。这个新提议的项目将在小鼠繁殖屏障（屏障支持19个PI实验室）的剩余房间中增加5个通风鼠架，这些鼠架将购买大笼子（180英寸/个笼子- 36个笼子/个笼子），可以通过与小笼子（75英寸/个笼子）交换在繁殖屏障的任何架子上使用（2个小笼子适合1个大笼子）。我们建议在繁殖屏障中设置大型笼子，以使我们能够根据第八版NIH指南推荐的每只繁殖雌性提供足够的空间来支持三合一繁殖。其次，我们建议在SPF （specific pathogen free， SPF）研究组的4个小鼠房间中翻新并增加20个通风机架（5个机架/房间）。这些拟议的通风机架是单面单元，每个单元可容纳72个笼子（75英寸/笼子）。这种机架形式将允许我们增加25%的房间笼子容量（288到360个笼子）。该SPF小鼠研究套件目前支持41个PI实验室。这些房间目前已接近容量，并且有3名具有小鼠研究项目的新教师计划在2014年1月之前将他们的小鼠转移到ARF。三名教员中有两名是癌症中心的成员我们的目标是让他们与其他小鼠癌症研究用户一起工作。该项目将增加该套件的容量以支持这一目标。SPF小鼠研究套房的两个手术室目前有中央氧气和吸入异氟烷麻醉装置，通过我们的建筑排气清除废弃的麻醉气体。其中一个房间有一个II级A2生物安全柜，可以保护老鼠免受潜在的微生物污染和操作人员的安全（仅限颗粒）。其中一个房间的案例作业是木制的，两个房间的案例作业的数量和格式不足以支持我们在这个套件中的用户。因此，我们建议升级两个手术室的病例室，通过隔离的安全设备存储来提高功能，在其中一个手术室中增加一个新的病例池，并增加一个移动HEPA过滤手术站。总的来说，本项目是由静态微隔离鼠笼向通风鼠笼过渡的延续。该项目的完成对我们继续实现我们的战略和计划目标至关重要，这些目标是：扩大NIH和新墨西哥大学HSC之间的富有成效的伙伴关系；加强对HSC标志性项目（脑和行为疾病、癌症、心血管和代谢疾病、儿童健康、环境健康、传染病和免疫）的支持；在我们的临床和转化科学中心奖（CTSC）中，扩大与ARF新兴协同效应的发展，将其作为技术核心之一；提高动物护理依从性；并维持自1973年以来HSC一直保持的AAALAC认证。该项目的新设备将通过改善动物房间和笼子的空气质量，通过笼子的通风和建筑物的排气来改善动物护理，并通过节约能源和水（减少频繁更换笼子/卫生）来提高新墨西哥大学的可持续发展目标。人工和笼子用品的成本也会降低，这将降低核心用户的成本升级。总之，我们通过跨学科的CTSC不断寻求加快发现步伐的方法，CTSC的总体目标是促进更健康的公众和更负担得起的患者护理。

DESCRIPTION (provided by applicant): The aim of this G20 proposal entitled "UNM Health Sciences Center Animal Resource Facility Improvement" is a request for $499,967 to: 1) support purchase of 25 ventilated mouse racks with cages/accessories and associated mechanical and electrical construction to provide connection of these units to building exhaust and electrical in four of the five SPF mouse rooms (the 5th room is in the mouse breeding barrier and connections were installed during a recent renovation) (1261 gsf / 1159 nsf). 2) To upgrade 2 procedures rooms (399 gsf / 352 nsf) in the SPF mouse research suite to remove old and add new casework and purchase a 5 foot HEPA filtered animal procedure station to be located in one of the procedure rooms. The total space affected by this project is 1,660 gsf / 1,511 nsf, and it includes space where equipment is sited and/or renovation at the University of New Mexico (UNM) Health Sciences Center (HSC) Animal Resource Facility (ARF). This ARF project is located in contiguous space within the Biomedical Research Facility (BRF) and the Basic Medical Sciences Building (BMSB). The BRF/BMSB animal facilities comprise the major component of ARF but the HSC ARF also includes housing/research in two HSC satellite imaging facilities. This project builds upon improvements from three previous renovation projects completed in the BRF and BMSB ARF in 2002 and 2008, and 2013. These past renovations upgraded mechanical (HVAC with DDC controls and environmental alarms), floors, finishes and roofing and the most recent project (2012 G20 award $500K plus $82K institutional match) replaced a 26 year old tunnel washer, renovated 4 rooms and added 16 ventilated mouse racks to 3 of the 4 rooms in the mouse breeding barrier. This new proposed project will add five ventilated mouse racks to the remaining room in the mouse breeding barrier (barrier supports 19 PI laboratories) that will be purchased with the large cages (180 in2/cage - 36 cages/rack) that can be used in any rack in the breeding barrier by interchanging with small cages (75 in2/cage) (2 small cages fit in the slot for 1 large cage). We propose the large cages in the breeding barrier to allow us to support trio breeding with adequate space per breeding female recommended under the 8th edition NIH guide. Second we propose to renovate and add 20 ventilated racks (5 racks/room) in the 4 mouse rooms in the specific pathogen free (SPF) research suite. These proposed ventilated racks are single sided units with capacity of 72 cages (75 in2 /cage) per unit. This rack format will allow us to increase room cage capacity by 25% (288 to 360 cages). This SPF mouse research suite currently supports 41 PI laboratories. These rooms are currently near capacity and 3 new faculty with mouse research programs plan to transfer their mice to the ARF by January 2014. Two of the 3 faculty are members of the Cancer Center and our goal is to co-locate them with the rest of our mouse cancer research users. This project will increase capacity in this suite to support this goal. The two procedure rooms in the SPF mouse research suite currently have central oxygen gases and inhalant isoflurane anesthesia units with waste anesthetic gas scavenging provided through our building exhaust. One of the rooms has a Class II A2 Biosafety Cabinet that provides protection to the mice from potential microbiological contamination and operator safety (particulate only). The casework in one of the rooms is wooden and the quantity and format of the casework in both rooms is insufficient to support our users in this suite. Therefore, we propose to upgrade casework in the two procedure rooms to improve functionality with segregated secure equipment storage, add a new sink with the casework in one of the procedure rooms and add a mobile HEPA filter procedure station. In general, this project is a continuation to transition from static microisolatr mouse cages to ventilated cages. Completion of the project is critical for us to continue meeting our strategic and programmatic goals which are to: expand a productive partnership between the NIH and UNM HSC; enhance our support to the HSC Signature Programs (Brain and Behavioral Illnesses, Cancer, Cardiovascular and Metabolic Disease, Child Health, Environmental He0alth, and Infectious Diseases and Immunity); expand development of new emerging synergies with ARF as one of the technology cores within our Clinical and Translational Science Center Award (CTSC); improve animal care compliance; and sustain AAALAC accreditation which HSC has continued since 1973. New equipment under this project will improve animal care by improving animal room and cage air quality with ventilation of the cages and exhaust from the building and enhance UNM'S sustainability goals by saving energy and water (less frequent cage changing/sanitation). The cost of labor and cage supplies will also be reduced which will lower cost escalation to core users. In conclusion, we continually seek ways to accelerate the pace of discoveries through our interdisciplinary CTSC which has overarching goals to promote a healthier public and more affordable patient care.