NICHD Cooperative Multicenter Neonatal Research Network

描述（由申请人提供）：根据RFA-HD-10-003的要求，全国儿童医院新生儿科和俄亥俄州立大学提交此申请，希望加入尤妮斯·肯尼迪·施莱弗NICHD合作多中心新生儿研究网络。学院的优势包括：1)一个真正的学术部门，由19名临床教职员工组成，具有卓越的临床研究记录；2)可供临床研究的庞大且医学多样化的人群，2009年有2,197名新生儿重症监护病房入院，其中615名<= 32周孕龄，539名<1500克出生体重；3)与母胎医学的活跃合作关系，以及我们机构与NICHD MFMU之间长期成功的合作关系。4)一个充满活力的围产期研究中心设在研究所，其中包括一个充满活力的临床研究企业俄亥俄州围产期研究网络，5)一个强有力的机构承诺，以预防早产及其并发症。事实上，预防早产是NCH战略计划的重点。所有这些优势都将极大地促进NICHD NRN研究。此外，我们的人口非常容易接受和同意参与与早产有关的临床研究。我们的临床能力影响深远，基本上包括为早产儿提供的所有服务。我们有一个新生儿随访项目已被证明特别适合临床协议中受试者的随访。我们的概念应用程序题为“开发早产儿个性化医疗方法”，将新生儿学，遗传学，数学医学和生物统计学结合起来，开发针对早产儿并发症的个性化医疗方法。这个概念应用程序展示了我们在获取、存储和分析大量数据集方面的专业知识。这种专门知识对于未来几年NICHD NRN可能进行的任何“基因组”类型的研究都是必要的。我们的资产、丰富的临床资料、卓越的机构支持、MFM和新生儿学之间的卓越合作、专门的儿科研究机构的资源以及杰出的学术新生儿学家使NCH/OSU成为NICHD NRN的理想场所。

DESCRIPTION (provided by applicant): The Division of Neonatology of Nationwide Children's Hospital and The Ohio State University submits this application to join the Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network in response to RFA-HD-10-003. Strengths of our Institution include: 1) a truly academic Division that consists of 19 clinical faculty members with an exceptional record of clinical research, 2) a large and medically diverse population available for clinical studies with 2,197 NICU admissions in 2009 of which 615 were <= 32 weeks gestational age and 539 were <1500 grams birthweight, 3) a vibrant collaborative relationship with maternal-fetal medicine and a long and successful relationship between our institution and the NICHD MFMU, 4) a dynamic Center for Perinatal Research housed in the Research Institute, which includes a vigorous clinical research enterprise the Ohio Perinatal Research Network, and 5) a robust Institutional commitment to preventing prematurity and its complications. Indeed, preventing prematurity is the focus of NCH's strategic plan. All of these strengths will contribute greatly to NICHD NRN studies. Furthermore, our population is very receptive and agreeable to participation in clinical studies related to preterm birth. Our clinical capabilities are far reaching and include essentially every service offered to preterm neonates. We have a neonatal follow-up program that has proven to be particularly well suited to follow-up of subjects in clinical protocols. Our concept application entitled, "Developing a Personalized Medicine Approach to Preterm Infants", brings together neonatology, genetics, mathematical medicine, and biostatistics to develop a personalized medicine approach to the complications of prematurity. This concept application demonstrates our expertise in acquiring, storing and analyzing vast data sets. This expertise will be necessary for any "omic" types of studies that the NICHD NRN may undertake in the years to come. Our assets, abundant clinical material, outstanding institutional support, exceptional collegiality between MFM and neonatology, the resources of a dedicated pediatric research institute, and outstanding academic neonatologists make NCH/OSU an ideal site for the NICHD NRN.